Evidence map›Paper›PMID 31998024›Full record

ReviewSaudi journal of anaesthesia

Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends.

G V Krishna Prasad, Sangeeta Khanna, Sharma Vipin Jaishree

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Saudi journal of anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04900116 (Comparison of Local Anesthetic Dose in PENG), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04900116 nacompletednot on this map

Comparison of Local Anesthetic Dose in PENG (Pericapsular Nerve Group) Block Performed for Postoperative Analgesia in Total Hip Replacement Operations

TypeinterventionalSponsorIstanbul UniversityRan2021 to 2022Enrolled84ConditionsPain, PostoperativeArmsBupivacaine HCl 0.5 % in 20 ML Injection, Bupivacaine HCl 0.25 % in 20 ML Injection, Bupivacaine HCl 0.125 % in 20 ML Injection, NaCl 0.9%
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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  19. Multimodal Pain Management in Orthopedic Surgery.Journal of clinical medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

G V Krishna PrasadDepartment of Anaesthesiology, Military Hospital, Kirkee, Range Hills, Pune, Maharashtra, India.
Sangeeta KhannaDepartment of Anaesthesiology, Military Hospital, Kirkee, Range Hills, Pune, Maharashtra, India.
Sharma Vipin JaishreeDepartment of Anaesthesiology, Military Hospital, Kirkee, Range Hills, Pune, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent anesthetic practice, peripheral nerve blocks (PNBs) are used extensively for surgical anesthesia and nonsurgical analgesia. PNBs offer many benefits over other anesthetic techniques in a certain population of patients, and in some specific clinical setting, that may contribute to faster and safer pain relief, increased patient satisfaction, reduced hospital stay, and decreased overall healthcare cost. The technique involves the injection of the anesthetic in the vicinity of a specific nerve or bundle of nerves to block the sensation of pain transmitting to a specific portion of the body. However, the length of analgesia when a single anesthetic is used for PNB may not last long. Therefore, the practice of adding an additional agent called adjuvant has been evolved to prolong the analgesic effect. There are many such adjuvants available that are clinically being used for this purpose imparting great efficacy and safety to the anesthetic process. The adjuvants molecules are generally classified as opioids, alpha-2 agonist, steroids, etc. Most of them are safe to use and show little or no adverse event related to neurotoxicity and tissue damage. Although there is extensive use of such adjuvants in the clinical field, none of the molecules is approved by the FDA and is used as an off-label drug. The risk to benefit ratio must be assessed while using such an agent. This review will try to delineate the basic need of adjuvant in peripheral nerve block and will discuss the advantages and limitations of using different adjuvants and will discuss the future prospect of such application.

Indexed as

Additivealpha-2 agonistsanalgesiaopioidsperipheral nerve blocksteroid

Identifiers

PMID31998024
PMCPMC6970354
OpenAlexW2999752332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.