ArticleClinical ophthalmology (Auckland, N.Z.)2019
Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma.
Article in Clinical ophthalmology (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- APSified Peripapillary Vessel Density in Glaucoma Suspects and Open-Angle Glaucoma.Diagnostics (Basel, Switzerland) · 2026Article
- Photoplethysmography for Assessing Microcirculation in Hypertensive Patients After Taking Antihypertensive Drugs: A Review.Journal of multidisciplinary healthcare · 2024Review
- Macular and Peripapillary Vascular Densities in Non-Glaucomatous Eyes of Patients with Unilateral Glaucoma.Turkish journal of ophthalmology · 2023Article
- OCTA and Doppler Ultrasound in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma.Life (Basel, Switzerland) · 2023Article
- Comparative analysis of retinal photoplethysmographic spatial maps and thickness of retinal nerve fiber layer.PloS one · 2023Article
- Optical Coherence Tomography Angiography (OCTA) Differences in Vessel Perfusion Density and Flux Index of the Optic Nerve and Peri-Papillary Area in Healthy, Glaucoma Suspect and Glaucomatous Eyes.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Radial peripapillary vessel density as early biomarker in preperimetric glaucoma and amnestic mild cognitive impairment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma.American journal of ophthalmology · 2021Article
- Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.Journal of current ophthalmologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate vessel density (VD) of radial peripapillary capillaries (RPC) and structural alterations in patients with unilateral preperimetric glaucoma (PPG) using optical coherence tomography angiography (OCTA).
methodsThis cross-sectional observational study included 13 untreated patients with unilateral PPG. PPG eyes had larger excavation and abnormal thinning of retinal nerve fiber layer (RNFL) and/or ganglion cell complex (GCC) compared with fellow eyes (F). Both RNFL and GCC thickness in F were statistically within normal limits and/or borderline. The RPC VD on optic disc (idVD), of peripapillary (ppVD) and whole image (wiVD) scan area was measured. Twenty healthy eyes (H) served as controls. Structural and vascular parameters obtained by spectral-domain OCT/OCTA (Optovue; Fremont, CA) were compared between PPG, F and H.
resultsMean RNFL and GCC average thickness in microns differed significantly (p<0.001) between PPG (82.4±7.1, 81.4±5.9), F (91.0±7.1, 88.5±3.8) and H (103.5±6.0, 99.3±5.7). PPG compared with F showed significantly (p<0.001) lower mean ppVD (43.8%±3.0% versus 47.8%±3.2%) and wiVD (45.9%±3.5% versus 50.1%±3.9%). Mean ppVD (49.7%±2.4%) and wiVD (52.6%±3.0%) in H were not significantly higher than in F. Mean idVD showed no significant differences among the 3 groups. Areas under the receiver operating characteristic curves (AUROCs) for RNFL, GCC, ppVD and wiVD between PPG and H were excellent (>0.9). AUROCs between F and H demonstrated an excellent diagnostic ability for structural parameters and a poor one (<0.7) for vascular parameters.
conclusionAffected eyes of patients with unilateral PPG demonstrated significant RPC dropout. Clinically unaffected eyes showed thinner structural parameters but no significant microvasculature differences compared with non-glaucomatous eyes. Diagnostic ability of peripapillary vascular parameters was not superior to structural measurements. Microvascular dysfunction seems to be an early but not a primary event in glaucoma continuum at the stage of undetectable visual field loss. OCTA can be useful in early glaucoma diagnosis.
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