Evidence map›Paper›PMID 31997656›Full record

ArticleCartilage2021

Analysis of Association between Morphometric Parameters of Growth Plate and Bone Growth of Tibia in Mice and Humans.

Kimberly Wilson, Yu Usami, Danielle Hogarth, Amanda L Scheiber, Hongying Tian, Takeshi Oichi, Yulong Wei, Ling Qin, Satoru Otsuru, Satoru Toyosawa and 3 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  3. Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kimberly WilsonDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Yu UsamiDepartment of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Danielle HogarthDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Amanda L ScheiberDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Hongying TianDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Takeshi OichiDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Yulong WeiMckay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ling QinMckay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Satoru OtsuruDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Satoru ToyosawaDepartment of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Masahiro IwamotoDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Joshua M AbzugDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.
Motomi Enomoto-IwamotoDepartment of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-9589-9607
University of Maryland, Baltimore · USThe University of Osaka · JPUniversity of Pennsylvania · US

Funding

Regulation of Skeletal Growth by Nuclear Retinoid ReceptorsR01AR056837 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI IWAMOTO, MASAHIRO, PACIFICI, MAURIZIO · 2009 to 2020
$3.4M
Local Control of endochondral ossification by retinoid-loaded nano-particlesR01AR072713 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI CHORNY, MICHAEL, IWAMOTO, MASAHIRO · 2018 to 2022
$1.8M
Advanced components for an existing spinning disk confocal in an established core imaging facilityS10OD026698 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2019 to 2019
$274k
NIAMS NIH HHS R01 AR056837NIAMS NIH HHS R01 AR072713NIH HHS S10 OD026698
6 · The paper itself

Abstract

objectiveThe purposes of this study are to evaluate which growth plate parameters are associated with bone growth in mice and to compare the mouse results with those in humans.

designThe sagittal sections of the proximal growth plate of the mouse tibia from neonate to young adult stages were subjected to histomorphometric and functional analyses. The radiographic images of tibias of human patients until puberty were analyzed to obtain the tibia length and the proximal growth plate height. It was found that a linear correlation best modeled the relationship between the growth plate variables with the tibia growth rate and length.

resultsIn mice, total height, resting zone height, combined height of the proliferation and prehypertrophic zones, proliferation activity, and the total width of tibia growth plate showed high linear correlation with tibia bone length and bone growth rate, but the hypertrophic zone height and the growth plate area did not. In both mice and humans, the total growth plate width of tibia was found to have the strongest correlation with tibia length and growth rate.

conclusionsThe results validated that growth plate total height, the height of the resting zone and cell proliferation activity are appropriate parameters to evaluate the balance between growth plate activity and bone growth in mice, consistent with previous reports. The study also provided a new growth plate parameter candidate, growth plate width for growth plate activity evaluation in both mouse and human tibia bone.

Indexed as

Growth PlateTibiaAnimalsBone and BonesBone DevelopmentHumansHypertrophyMicebone growthgrowth platehistomorphometrymousepostnatal growth

Identifiers

PMID31997656
PMCPMC8804827
OpenAlexW3004005451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.