Evidence map›Paper›PMID 31997628›Full record

ArticleYonsei medical journal2020

Eun Lee, Mi Jin Kang, Jeong Hyun Kim, Seung Hwa Lee, So Yeon Lee, Hyun Ju Cho, Jisun Yoon, Sungsu Jung, Yangsoon Park, Dong Kyu Oh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Eun LeeDepartment of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.ORCID https://orcid.org/0000-0002-0145-7067
Mi Jin KangAsan Medical Center, Asan Institute for Life Sciences, Environmental Health Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-8510-3268
Jeong Hyun KimDepartment of Medicine, University of Ulsan Collage of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4879-0075
Seung Hwa LeeAsan Medical Center, Asan Institute for Life Sciences, Environmental Health Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-9359-0318
So Yeon LeeDepartment of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2499-0702
Hyun Ju ChoDepartment of Pediatrics, International St. Mary's hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0003-4282-4000
Jisun YoonDepartment of Pediatrics, Mediplex Hospital, Incheon, Korea.ORCID https://orcid.org/0000-0002-4904-9118
Sungsu JungDepartment of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0002-0559-4982
Yangsoon ParkDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2832-3525
Dong Kyu OhDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-7511-9634
Sang Bum HongDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2737-7695
Soo Jong HongDepartment of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr.ORCID https://orcid.org/0000-0003-1409-2113
Ulsan College · KRAsan Medical Center · KRCatholic Kwandong University International St. Mary's Hospital · KRChonnam National University Hospital · KRIncheon Medical Center · KRPusan National University Yangsan Hospital · KR

Funding

Environmental Health Center for Hazardous Chemical ExposureMinistry of Environment 2016001360006
6 · The paper itself

Abstract

An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlying HDLI have yet to be conducted. This study aimed to investigate methylation changes and their potential role in HDLI after exposure to HDs containing polyhexamethylene guanidine-phosphate. DNA methylation analysis was performed in blood samples from 10 children with HDLI and 10 healthy children using Infinium Human MethylationEPIC BeadChip. Transcriptome analysis was performed using lung tissues from 5 children with HDLI and 5 controls. Compared to healthy controls, 92 hypo-methylated and 79 hyper-methylated CpG sites were identified in children with HDLI at the statistical significance level of |Δβ|>0.2 and

Indexed as

HumidifiersSignal TransductionChildDisinfectantsDNA MethylationFemaleGene Expression RegulationGene Regulatory NetworksGuanidinesHumansLung InjuryMaleReceptor, Notch1Republic of KoreaDisinfectantsGuanidinespolyhexamethyleneguanidineReceptor, Notch1Humidifier disinfectantmethylationNOTCH1polyhexamethylene guanidinepulmonary fibrosis

Identifiers

PMID31997628
PMCPMC6992453
OpenAlexW3003168499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.