Evidence map›Paper›PMID 31997582›Full record

ArticleCancer medicine2020

Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population.

Qiaoyun Guo, Linping Xu, Rui Peng, Yan Ma, Yanli Wang, Feifei Chong, Mengmeng Song, Liping Dai, Chunhua Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Qiaoyun GuoDepartment for Endemic Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, PR China.
Linping XuDepartment of Teaching and Research, Henan Tumor Hospital, Zhengzhou, Henan, PR China.
Rui PengDepartment of Teaching and Research, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Yan MaHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, China.
Yanli WangDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.ORCID 0000-0003-0493-8998
Feifei ChongDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Mengmeng SongDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Liping DaiDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.ORCID 0000-0002-5531-1776
Chunhua SongDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.ORCID 0000-0001-6028-5923
Zhengzhou University · CNHenan Cancer Hospital · CNLuoyang Orthopedic-Traumatological Hospital of Henan Province · CNThird Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim was to evaluate the association between the LINC00520 genetic polymorphisms and breast cancer (BC) susceptibility.

methodsNine single-nucleotide polymorphisms (SNPs) on LINC00520 genotyping were performed in 504 BC patients and 505 cancer-free controls in Chinese Han population to study the relationship between LINC00520 polymorphism and BC susceptibility. qRT-PCR and luciferase tests were used to explore how rs12880540 affected the expression of LINC00520.

resultsThe genotype GG (OR:3.58, 95%CI:1.32-9.69) in rs8012083 increased the risk of triple-negative BC. The genotype GG (OR:0.31, 95%CI:0.14-0.69) in rs8012083, the genotype AA (OR:2.74, 95%CI:1.01-7.42) in rs2152275, and genotype TG (OR:1.62, 95%CI:1.04-2.52) in rs12880540 were associated with HER-2 status. The dominant (OR:0.65, 95%CI:0.45-0.95) and overdominant genetic model (OR:0.67, 95%CI:0.46-0.98) consistently showed that rs11622641 T was significantly associated with lower risk of BC. Similarly, the recessive genetic model (OR:1.57, 95%CI:1.07-2.30) of rs12880540 and the dominant (OR:1.62, 95%CI:1.24-2.11) and overdominant (OR:1.56, 95%CI:1.19-2.03) genetic model of rs2152278 may increase the risk of BC. The relative expression of LINC00520 increased linearly with the increase in the number of rs12880540 mutations. rs12880540 alleles were due to the interaction between LINC00520 and miR-3122 at T, but the mutation of rs12880540 G > T had no effect on the binding ability of LINC00520 and miR-3122.

conclusionA genetic variant of rs8012083 in LINC00520 may be used as a biomarker for triple-negative BC after further evaluation of diagnostic tests. The genetic variant of LINC00520 was related to the susceptibility of BC, and rs12880540 might affect the corresponding mRNA expression of lncRNA LINC00520.

Indexed as

Genetic Predisposition to DiseaseAdultAllelesAsian PeopleBiomarkers, TumorChinaFemaleGene Expression Regulation, NeoplasticGene FrequencyHumansMiddle AgedMolecular EpidemiologyPolymorphism, Single NucleotideRNA, Long NoncodingRNA, MessengerTriple Negative Breast NeoplasmsBiomarkers, TumorRNA, Long NoncodingRNA, Messengerbreast cancerLINC00520lncRNAsingle-nucleotide polymorphismssusceptibility

Identifiers

PMID31997582
PMCPMC7064040
OpenAlexW3003877561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.