Evidence map›Paper›PMID 31997501›Full record

ArticleInternational journal of experimental pathology2019

The density of infiltrating T cells and macrophages in the parental tumour correlates with growth rate of tumoroids established from colorectal adenocarcinoma.

Nabi Mousavi, Anna Josefine Bang Jespersen, Lars Nannestad Jorgensen, Vera Timmermans, Steffen Heegaard

Abstract read
In one paragraph

Article in International journal of experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nabi MousaviDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3696-8203
Anna Josefine Bang JespersenDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lars Nannestad JorgensenDigestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Vera TimmermansDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Steffen HeegaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate the correlation between the density of infiltrating T cells and macrophages in the parental colorectal cancer (CRC) and the growth rate of tumoroids (i.e. a patient-derived in vitro 3D model). Tumoroids were established from fresh specimens of primary and metastatic CRC from 29 patients. The in vitro growth rate of tumoroids was monitored by automated imaging. The density of infiltrating T cells and macrophages was determined in the centre of the tumour (CT) and at the invasive margin (IM) of the parental tumours. This was performed by digital image analysis on the whole-slide scanned images using Visiopharm

Indexed as

AdenocarcinomaAgedAged, 80 and overBiomarkers, TumorColorectal NeoplasmsComputer SimulationFemaleHumansLymphocytes, Tumor-InfiltratingMacrophagesMaleMiddle AgedModels, BiologicalNeoplasm InvasivenessT-LymphocytesBiomarkers, Tumorcolorectal adenocarcinomadigital pathologyin vitro 3D culturetumour-associated macrophagestumour-associated T lymphocytes

Identifiers

PMID31997501
PMCPMC7042731
OpenAlexW3003915922

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.