Evidence map›Paper›PMID 31997435›Full record

ArticleCancer science2020

Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc

Makiko Kawaguchi, Koji Yamamoto, Hiroaki Kataoka, Aya Izumi, Fumiki Yamashita, Takumi Kiwaki, Takahiro Nishida, Eric Camerer, Tsuyoshi Fukushima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. PARs in the inflammation-cancer transformation of CRC.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  11. Article
  12. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Makiko KawaguchiDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.ORCID https://orcid.org/0000-0001-8210-5460
Koji YamamotoDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.
Hiroaki KataokaDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.ORCID https://orcid.org/0000-0001-9948-0451
Aya IzumiDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.
Fumiki YamashitaDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.
Takumi KiwakiDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.
Takahiro NishidaDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.
Eric CamererInserm U970, Paris Cardiovascular Research Center, Université de Paris, Paris, France.
Tsuyoshi FukushimaDepartment of Pathology, University of Miyazaki, Miyazaki, Japan.ORCID https://orcid.org/0000-0002-9350-777X
University of Miyazaki · JPInserm · FR

Funding

Agence Nationale de la Recherche ANR-15-CE14-0009Japan Society for the Promotion of Science KAKENHI 15K08311Japan Society for the Promotion of Science KAKENHI 16H05175Japan Society for the Promotion of Science KAKENHI 17K08764
6 · The paper itself

Abstract

Hepatocyte growth factor activator inhibitor-1 (HAI-1), encoded by the SPINT1 gene, is a membrane-bound protease inhibitor expressed on the surface of epithelial cells. Hepatocyte growth factor activator inhibitor-1 regulates type II transmembrane serine proteases that activate protease-activated receptor-2 (PAR-2). We previously reported that deletion of Spint1 in Apc

Indexed as

Adenomatous Polyposis Coli ProteinAnimalsCarcinogenesisDisease Models, AnimalEpithelial CellsHumansIntestinal NeoplasmsKallikreinsMiceNeovascularization, PathologicNF-kappa BProteinase Inhibitory Proteins, SecretoryReceptor, PAR-2Signal TransductionTranscription Factor RelAAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseF2rl1 protein, mouseKallikreinsNF-kappa BProteinase Inhibitory Proteins, SecretoryReceptor, PAR-2Rela protein, mouseSpint1 protein, mouseTranscription Factor RelAangiogenesiscolon cancerHAI-1PAR-2Spint1

Identifiers

PMID31997435
PMCPMC7156842
OpenAlexW3003977535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.