Evidence map›Paper›PMID 31997289›Full record

ArticleDrug safety2020

Adverse Events in Twitter-Development of a Benchmark Reference Dataset: Results from IMI WEB-RADR.

Juergen Dietrich, Lucie M Gattepaille, Britta Anne Grum, Letitia Jiri, Magnus Lerch, Daniele Sartori, Antoni Wisniewski

Abstract read
In one paragraph

Article in Drug safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Pharmacovigilance in the digital age: gaining insight from social media data.Experimental biology and medicine (Maywood, N.J.) · 2025
    Review
  4. Transformers and large language models in healthcare: A review.Artificial intelligence in medicine · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juergen DietrichPharmacovigilance, Bayer AG, Müllerstr. 170, 13353, Berlin, Germany. juergen.dietrich@bayer.com.ORCID 0000-0002-5494-3499
Lucie M GattepailleUppsala Monitoring Centre, Uppsala, Sweden.
Britta Anne GrumPharmacovigilance, Bayer AG, Müllerstr. 170, 13353, Berlin, Germany.
Letitia JiriGlobal Patient Safety Pharmacovigilance Operations, Amgen Limited, Cambridge, UK.
Magnus LerchLenolution GmbH, Berlin, Germany.
Daniele SartoriUppsala Monitoring Centre, Uppsala, Sweden.
Antoni WisniewskiGlobal Regulatory Affairs, Patient Safety and Quality Assurance, Global Medicines Development, AstraZeneca, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectiveSocial media has been suggested as a source for safety information, supplementing existing safety surveillance data sources. This article summarises the activities undertaken, and the associated challenges, to create a benchmark reference dataset that can be used to evaluate the performance of automated methods and systems for adverse event recognition.

methodsA retrospective analysis of public English-language Twitter posts (Tweets) was performed. We sampled 57,473 Tweets out of 5,645,336 Tweets created between 1 March, 2012 and 1 March, 2015 that mentioned at least one of six medicinal products of interest (insulin glargine, levetiracetam, methylphenidate, sorafenib, terbinafine, zolpidem). Products, adverse events, indications, product-event combinations, and product-indication combinations were extracted and coded by two independent teams of safety reviewers.

resultsThe benchmark reference dataset consisted of 1056 positive controls ("adverse event Tweets") and 56,417 negative controls ("non-adverse event Tweets"). The 1056 adverse event Tweets contained 1396 product-event combinations referring to personal adverse event experiences, comprising 292 different MedDRA

conclusionsA manually curated benchmark reference dataset based on Twitter data has been created and is made available to the research community to evaluate the performance of automated methods and systems for adverse event recognition in unstructured free-text information.

Indexed as

BenchmarkingSocial MediaAdverse Drug Reaction Reporting SystemsDatabases, FactualDrug-Related Side Effects and Adverse ReactionsHumansPharmacovigilanceUnited States

Identifiers

PMID31997289
PMCPMC7165158

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.