Evidence map›Paper›PMID 31997157›Full record

ArticleGenes & genomics2020

Transcriptomic analyses reveal novel genes with sexually dimorphic expression in Takifugu rubripes brain during gonadal sex differentiation.

Xufang Shen, Hongwei Yan, Lei Zhang, Zhen Yuan, Wenlei Liu, Yumeng Wu, Qi Liu, Xiaoyi Luo, Ying Liu

Abstract read
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In one paragraph

Article in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xufang ShenKey Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Hongwei YanKey Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China. yanhongwei_1985@hotmail.com.
Lei ZhangCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Zhen YuanCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Wenlei LiuCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Yumeng WuCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Qi LiuCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China. liuqisunson@163.com.ORCID 0000-0002-4730-4736
Xiaoyi LuoKey Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Ying LiuCollege of Marine Science and Environment Engineering, Dalian Ocean University, #52, Heishijiao Street, Shahekou District, Dalian, 116023, Liaoning, China.
Dalian Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantification of mRNAs in gonads and other tissues at the early critical development stage of sex differentiation may help to provide a global view of regulatory mechanisms underlying sex differentiation. We have recently reported the transcriptomic profiling of fugu gonad associated with sex differentiation.

objectivesThis study attempted to identify the genes in the brain that are involved in gonadal differentiation and development.

methodsIn this study, a transcriptomic scan of potential candidate genes involved in sex differentiation was conducted in the brains of fugu larvae at 30 and 40 dah (morphological gonadal sex differentiation had not yet occurred). The dimorphic expression patterns of several candidate genes were verified using quantitative PCR.

resultsA total of 28.24 Gb of clean reads were obtained and 22,337 genes were identified in the brains of fugu larvae. These included 1008 novel genes that provide abundant data for functional analysis of sex differentiation. 229 genes were identified in the 30 dah larvae that were abundant in the XY brain and 21 that were abundant in the XX brain. In the 40 dah larvae, 325 genes were identified abundant in the XY brain and 174 were identified abundant in the XX brain.

conclusionThis is the first investigation into the transcriptome of the fugu larvae brain at the early sex differentiation stage. The results obtained here will enhance the understanding of molecular mechanisms that underly fugu sex differentiation.

Indexed as

TranscriptomeAnimalsBrainFemaleFish ProteinsGene Expression Regulation, DevelopmentalGonadsMaleSex Determination ProcessesTakifuguFish ProteinsBrainDifferentially expressed geneEarly sex differentiationTakifugu rubripesTranscriptome analysis

Identifiers

PMID31997157
OpenAlexW3003341936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.