Evidence map›Paper›PMID 31997060›Full record

ArticleJournal of autism and developmental disorders2020

Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder.

Yumi Umesawa, Kanae Matsushima, Takeshi Atsumi, Toshihiro Kato, Reiko Fukatsu, Makoto Wada, Masakazu Ide

Open access · hybridAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  4. Article
  5. Vitamin BAnimals : an open access journal from MDPI · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yumi UmesawaDepartment of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa-shi, Saitama, 359-8555, Japan. umesawa-yumi@rehab.go.jp.ORCID http://orcid.org/0000-0001-8278-2146
Kanae MatsushimaDepartment of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto-shi, Kyoto, Japan.ORCID http://orcid.org/0000-0002-9947-8842
Takeshi AtsumiDepartment of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa-shi, Saitama, 359-8555, Japan.ORCID http://orcid.org/0000-0002-4547-6200
Toshihiro KatoDepartment of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto-shi, Kyoto, Japan.
Reiko FukatsuDepartment of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa-shi, Saitama, 359-8555, Japan.
Makoto WadaDepartment of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa-shi, Saitama, 359-8555, Japan.
Masakazu IdeDepartment of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa-shi, Saitama, 359-8555, Japan. ide-masakazu@rehab.go.jp.ORCID http://orcid.org/0000-0002-2704-9889
National Rehabilitation Center for Persons with Disabilities · JPKansai Medical University · JPKyorin University · JPKyoto University · JP

Funding

Japan Society for the Promotion of Science JP18H03140Japan Society for the Promotion of Science JP18H03663Japan Society for the Promotion of Science JP18K17914Meiji Yasuda Life Foundation of Health and Welfare 2017
6 · The paper itself

Abstract

Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using

Indexed as

AdolescentAdultAutism Spectrum DisorderBrainFemalegamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyMaleMotor CortexNeural InhibitionYoung Adultgamma-Aminobutyric AcidAutism spectrum disorderDevelopmental coordination disorderGamma-aminobutyric acidMagnetic resonance spectroscopyPrimary motor areaSupplementary motor area

Identifiers

PMID31997060
PMCPMC7374467
OpenAlexW3003961901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.