Evidence map›Paper›PMID 31996992›Full record

ArticleActa neuropathologica2020

cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas.

Daniel J Brat, Kenneth Aldape, Howard Colman, Dominique Figrarella-Branger, Gregory N Fuller, Caterina Giannini, Eric C Holland, Robert B Jenkins, Bette Kleinschmidt-DeMasters, Takashi Komori and 10 more

Abstract read
In one paragraph

Article in Acta neuropathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

292 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas.Archives of pathology & laboratory medicine · 2022
    Guideline
  6. Pooled it
  7. STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Trial
  8. Trial
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  10. Review
  11. Article
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232 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Daniel J BratDepartment of Pathology, Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Ward Building, 3-140, 303 E. Chicago Ave, Chicago, IL, 60611, USA. Daniel.brat@northwestern.edu.
Kenneth AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Howard ColmanDepartment of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Dominique Figrarella-BrangerService d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Marseille, France.
Gregory N FullerDepartment of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Caterina GianniniDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Eric C HollandDivision of Human Biology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Bette Kleinschmidt-DeMastersDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO, USA.
Takashi KomoriDepartment of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
Johan M KrosDepartment of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.
David N LouisDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Catriona McLeanAlfred Anatomical Pathology and NNF, Victorian Brain Bank, Carlton, VIC, Australia.
Arie PerryDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Guido ReifenbergerDepartment of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
Chitra SarkarDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Roger StuppRobert H. Lurie Cancer Center, Malnati Brain Tumor Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Martin J van den BentDepartment of Neurology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
Michael WellerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

Funding

Genomic Biomarkers of CancerZIABC011850 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2019 to 2025
$5.1M
Identification and targeting of mechanisms specific to glioma stem cells in glioblastomaR01CA214928 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BRAT, DANIEL J · 2018 to 2022
$1.8M
Intramural NIH HHS ZIA BC011850NCI NIH HHS R01 CA214928
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AstrocytomaBrain NeoplasmsHumansIsocitrate DehydrogenaseMutationNeoplasm GradingTerminology as TopicWorld Health OrganizationIDH1 protein, humanIsocitrate Dehydrogenase

Identifiers

PMID31996992
PMCPMC8443062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.