Evidence map›Paper›PMID 31996985›Full record

SynthesisWorld journal of surgery2020

Preoperative Antisepsis with Chlorhexidine Versus Povidone-Iodine for the Prevention of Surgical Site Infection: a Systematic Review and Meta-analysis.

Shi Chen, Jun Wu Chen, Bin Guo, Chun Cheng Xu

Registry-linked trialAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574090 (PROTOP), which is not on this map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03574090 phase4completednot on this map

PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery

TypeinterventionalSponsorUniversitat Internacional de CatalunyaRan2020 to 2023Enrolled268ConditionsSurgical Wound Infection, Postoperative Wound Infection, Postoperative Wound Infection Superficial Incisional, Preventive TherapyArmsAmoxicillin Clavulanate, Physiological Saline
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shi ChenDepartment of Orthopedics, Ninghai Medical Center First Hospital, 142 Taoyuan Road, Ninghai County, Ningbo City, 315600, Zhejiang Province, China. chenshi65536811@126.com.ORCID 0000-0003-1062-2682
Jun Wu ChenDepartment of Orthopedics, Ninghai Medical Center First Hospital, 142 Taoyuan Road, Ninghai County, Ningbo City, 315600, Zhejiang Province, China.
Bin GuoDepartment of Orthopedics, Ninghai Medical Center First Hospital, 142 Taoyuan Road, Ninghai County, Ningbo City, 315600, Zhejiang Province, China.
Chun Cheng XuDepartment of Orthopedics, Ninghai Medical Center First Hospital, 142 Taoyuan Road, Ninghai County, Ningbo City, 315600, Zhejiang Province, China.
Ninghai County First Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveChlorhexidine (CH) and povidone-iodine (PI) are the most commonly used preoperative skin antiseptics at present. However, the prevention of the surgical site infection (SSI) and the incidence of skin adverse events do not reach a consistent statement and conclusion. This meta-analysis aimed to evaluate the efficacy of chlorhexidine and povidone-iodine in the prevention of postoperative surgical site infection and the incidence of corresponding skin adverse events.

methodSubstantial studies related to "skin antiseptic" and "surgical site infection" were consulted on PUBMED, Web of Science, EMBASE, and CNKI. The primary outcome was the incidence of postoperative SSI. The secondary outcome was associated with skin adverse events. All data were analyzed with Revman 5.3 software.

resultsA total of 30 studies were included, including 29,006 participants. This study revealed that chlorhexidine was superior to povidone-iodine in the prevention of postoperative SSI (risk ratio [RR], 0.65; 95% confidence interval [CI], 0.55-0.77; p < 0.00001, I

conclusionChlorhexidine was superior to povidone-iodine in preventing postoperative SSI, especially for the clean-contaminated surgery. However, there was no statistically significant difference in the incidence of skin adverse events between CH and PI groups.

Indexed as

Preoperative CareAnti-Infective Agents, LocalAntisepsisChlorhexidineHumansPovidone-IodineSurgical Wound InfectionAnti-Infective Agents, LocalChlorhexidinePovidone-Iodine

Identifiers

PMID31996985
OpenAlexW3003533890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.