Evidence map›Paper›PMID 31996933›Full record

ReviewHNO2020

Immunotherapeutics for head and neck squamous cell carcinoma stem cells.

X Qian, F Leonard, Y Wenhao, H Sudhoff, T K Hoffmann, S Ferrone, A M Kaufmann, A E Albers

Abstract readReview
PubMed Publisher
In one paragraph

Review in HNO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

X QianInstitute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
F LeonardDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Y WenhaoDepartment of Otolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
H SudhoffDepartment of Otolaryngology, Head and Neck Surgery, Medizinische Fakultät OWL, Klinikum Bielefeld, Universität Bielefeld, Bielefeld, Germany.
T K HoffmannDepartment of Otolaryngology, Head and Neck Surgery, University of Ulm, Ulm, Germany.
S FerroneDepartment of Surgery, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
A M KaufmannClinic for Gynecology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
A E AlbersDepartment of Otolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. andreas.albers@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.

Indexed as

Head and Neck NeoplasmsImmunotherapySquamous Cell Carcinoma of Head and NeckCell Line, TumorHumansNeoplastic Stem CellsCancer nanomedicineCancer stem cellCancer vaccineImmunotherapyNanotechnology

Identifiers

PMID31996933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.