Evidence map›Paper›PMID 31996877›Full record

ArticleEnvironmental science. Processes & impacts2020

Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease.

Briana R De Miranda, J Timothy Greenamyre

Open access · greenAbstract read
In one paragraph

Article in Environmental science. Processes & impacts, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Genetic and environmental risk factors of Parkinsonism.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Smoking and the risk of prostate cancer: a review of risk and disease progression.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  10. Environmental Risk Factors for Parkinson's Disease: A Critical Review and Policy Implications.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  11. Review
  12. Review
  13. Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  18. Review
  19. Review
  20. DNA Damage and Parkinson's Disease.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Briana R De MirandaPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, 3501 Fifth Avenue, BST-7045, Pittsburgh, 15260, Pennsylvania, USA. brd73@pitt.edu.
J Timothy Greenamyre
University of Pittsburgh · US

Funding

alpha-Synuclein Inhibition of Mitochondrial Protein ImportR01NS095387 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENAMYRE, J TIMOTHY · 2015 to 2019
$2.2M
Role of LRRK2 in idiopathic Parkinson's diseaseR01NS100744 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENAMYRE, J TIMOTHY · 2017 to 2021
$1.7M
Environmental Mitochondrial Toxicants Cause LRRK2 Activation in Parkinson's DiseaseR00ES029986 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE MIRANDA, BRIANA · 2020 to 2022
$747k
A slowly progressive, endogenous synucleinopathy model of Parkinson's diseaseR21ES027470 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENAMYRE, J TIMOTHY · 2017 to 2018
$427k
Environmental Mitochondrial Toxicants Cause LRRK2 Activation in Parkinson's diseaseK99ES029986 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DE MIRANDA, BRIANA · 2019 to 2020
$220k
NIEHS NIH HHS K99 ES029986NIEHS NIH HHS R00 ES029986NIEHS NIH HHS R21 ES027470NINDS NIH HHS R01 NS095387NINDS NIH HHS R01 NS100744
6 · The paper itself

Abstract

Organic solvents are common chemicals used in industry throughout the world, however, there is evidence for adverse health effects from exposure to these compounds. Trichloroethylene (TCE) is a halogenated solvent that has been used as a degreasing agent since the early 20

Indexed as

Parkinson DiseaseTrichloroethyleneDopamineHumansIndustrySolventsDopamineSolventsTrichloroethylene

Identifiers

PMID31996877
PMCPMC7941732
OpenAlexW3000997499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.