ArticleSoft matter2020
Thermal fracture kinetics of heterogeneous semiflexible polymers.
Article in Soft matter, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change.European journal of cell biology · 2024Article
- Diffusive search and trajectories on tubular networks: a propagator approach.The European physical journal. E, Soft matter · 2021Article
- Structural basis of fast- and slow-severing actin-cofilactin boundaries.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The fracture and severing of polymer chains plays a critical role in the failure of fibrous materials and the regulated turnover of intracellular filaments. Using continuum wormlike chain models, we investigate the fracture of semiflexible polymers via thermal bending fluctuations, focusing on the role of filament flexibility and dynamics. Our results highlight a previously unappreciated consequence of mechanical heterogeneity in the filament, which enhances the rate of thermal fragmentation particularly in cases where constraints hinder the movement of the chain ends. Although generally applicable to semiflexible chains with regions of different bending stiffness, the model is motivated by a specific biophysical system: the enhanced severing of actin filaments at the boundary between stiff bare regions and mechanically softened regions that are coated with cofilin regulatory proteins. The results presented here point to a potential mechanism for disassembly of polymeric materials in general and cytoskeletal actin networks in particular by the introduction of locally softened chain regions, as occurs with cofilin binding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.