ArticleNature2020
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.
0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed
16.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 232 citations in OpenAlex.
- Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Trial
- Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.Nature medicine · 2026Article
- Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced CaNature cancer · 2026Article
- Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.Cell · 2026Article
- Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The New Tumor Predisposition Syndromes with Neuro-Oncological Relevance-A Comprehensive Review for Neuroradiologists.Clinical neuroradiology · 2026Review
- Transsynaptic tracing techniques to interrogate neuronal connectivity of glioblastomas.Nature protocols · 2026Review
- Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.Neuro-oncology · 2026Article
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.Neuro-oncology advances · 2026Review
- Merritt-Putnam Symposium | Tumor-Associated Epilepsy and Epilepsy-Associated Tumors: Exploring the Bidirectional Crosstalk Between Tumors and Seizures.Epilepsy currents · 2026Article
- Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.Signal transduction and targeted therapy · 2026Review
- CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Circular RNA PTPN4 Contributes to Blood-Brain Barrier Disruption during Early Epileptogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Increased neural excitability and glioma synaptic activity drives glioma proliferation in human cortex.Nature neuroscience · 2026Article
- Sinonasal renal cell-like adenocarcinoma: a case report and literature review.Diagnostic pathology · 2026Review
- The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition.Frontiers in molecular neuroscience · 2026Review
- Beyond synapses non-synaptic neural microenvironment interactions remodel circuits and drive glioma progression.Frontiers in oncology · 2026Review
- Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.Frontiers in neural circuits · 2026Review
103 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Kwanha Yu *Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Chia-Ching John Lin *Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Asante HatcherDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Brittney LozziCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Kathleen KongCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Emmet Huang-HobbsCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Yi-Ting ChengCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Vivek B BeecharCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Wenyi ZhuCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Yiqun ZhangDan L. Duncan Cancer Center, Division of Biostatistics, Baylor College of Medicine, Houston, TX, USA.
Fengju ChenDan L. Duncan Cancer Center, Division of Biostatistics, Baylor College of Medicine, Houston, TX, USA.
Gordon B MillsDepartment of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health Science University, Portland, OR, USA.
Carrie A MohilaDepartment of Pathology, Texas Children's Hospital, Houston, TX, USA.
Chad J CreightonDan L. Duncan Cancer Center, Division of Biostatistics, Baylor College of Medicine, Houston, TX, USA.
Jeffrey L NoebelsDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Kenneth L ScottDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.
Benjamin DeneenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. deneen@bcm.edu.
Baylor College of Medicine · USOregon Health & Science University · USTexas Children's Hospital · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MConsortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0MPLASTICITY IN DEVELOPING EPILEPTIC BRAINR01NS029709 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 1991 to 2025
$9.1MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MTranscriptional regulation of gliogenesis in the CNSR01NS071153 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2010 to 2022
$5.0MHelping Neuro-oncologists Navigate Expanded AccessR01CA217105 · NCI · STANFORD UNIVERSITY · PI BAINBRIDGE, MATTHEW NEIL, BONDY, MELISSA L. · 2018 to 2024
$4.7MIntegrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6MMOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA223388 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, NOEBELS, JEFFREY · 2018 to 2022
$3.5MNCI NIH HHS CA16672NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA217105NCI NIH HHS R01 CA223388NCI NIH HHS U01 CA217842NHGRI NIH HHS U54 HG006348NHLBI NIH HHS T32 HL092332NINDS NIH HHS R01 NS029709NINDS NIH HHS R01 NS071153
Abstract
Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment
Indexed as
AnimalsBrain NeoplasmsCarcinogenesisClass I Phosphatidylinositol 3-KinasesDisease Models, AnimalGlioblastomaGlypicansMiceClass I Phosphatidylinositol 3-KinasesGlypicansGPC3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.