ArticleScientific reports2020
Neural Representation of Observed, Imagined, and Attempted Grasping Force in Motor Cortex of Individuals with Chronic Tetraplegia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Observation-related activity in the human motor cortex increases with effector anthropomorphicity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Hierarchical and context-dependent encoding of actions in human posterior parietal and motor cortex.Cell · 2026Article
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Limb state accounts for differences between motor imagery and action in motor cortex.medRxiv : the preprint server for health sciences · 2026Article
- Hierarchical and Context-Dependent Encoding of Actions in Human Posterior Parietal and Motor Cortex.bioRxiv : the preprint server for biology · 2025Article
- Gesture encoding in human left precentral gyrus neuronal ensembles.Communications biology · 2025Article
- Your Body as a Tool to Learn Second Language Vocabulary.Behavioral sciences (Basel, Switzerland) · 2025Review
- Artificial Intelligence as a Replacement for Animal Experiments in Neurology: Potential, Progress, and Challenges.Neurology international · 2024Article
- Motor cortex retains and reorients neural dynamics during motor imagery.Nature human behaviour · 2024Article
- Entropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping - A Preliminary Report.Journal of motor behavior · 2024Article
- Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study.Frontiers in neuroscience · 2023Article
- Noninvasively recorded high-gamma signals improve synchrony of force feedback in a novel neurorehabilitation brain-machine interface for brain injury.Journal of neural engineering · 2022Article
- Feel Your Reach: An EEG-Based Framework to Continuously Detect Goal-Directed Movements and Error Processing to Gate Kinesthetic Feedback Informed Artificial Arm Control.Frontiers in human neuroscience · 2022Review
- Disentangling human grasping type from the object's intrinsic properties using low-frequency EEG signals.Neuroimage. Reports · 2021Article
- Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus.Journal of neural engineering · 2020Article
- The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia.eNeuroArticle
- Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 1 country.
Funding
Abstract
Hybrid kinetic and kinematic intracortical brain-computer interfaces (iBCIs) have the potential to restore functional grasping and object interaction capabilities in individuals with tetraplegia. This requires an understanding of how kinetic information is represented in neural activity, and how this representation is affected by non-motor parameters such as volitional state (VoS), namely, whether one observes, imagines, or attempts an action. To this end, this work investigates how motor cortical neural activity changes when three human participants with tetraplegia observe, imagine, and attempt to produce three discrete hand grasping forces with the dominant hand. We show that force representation follows the same VoS-related trends as previously shown for directional arm movements; namely, that attempted force production recruits more neural activity compared to observed or imagined force production. Additionally, VoS-modulated neural activity to a greater extent than grasping force. Neural representation of forces was lower than expected, possibly due to compromised somatosensory pathways in individuals with tetraplegia, which have been shown to influence motor cortical activity. Nevertheless, attempted forces (but not always observed or imagined forces) could be decoded significantly above chance, thereby potentially providing relevant information towards the development of a hybrid kinetic and kinematic iBCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.