Evidence map›Paper›PMID 31996465›Full record

Observational studyScience translational medicine2020

Different human resting memory CD4

Kyungyoon J Kwon, Andrew E Timmons, Srona Sengupta, Francesco R Simonetti, Hao Zhang, Rebecca Hoh, Steven G Deeks, Janet D Siliciano, Robert F Siliciano

Abstract readObservational Study
In one paragraph

Observational study in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Proviruses in CD4Science translational medicine · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyungyoon J KwonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6373-7144
Andrew E TimmonsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Srona SenguptaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8426-4905
Francesco R SimonettiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4165-660X
Hao ZhangFlow Cytometry and Immunology Core, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rebecca HohDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5112-4220
Steven G DeeksDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6371-747X
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6712-3775
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rsiliciano@jhmi.edu.ORCID 0000-0002-1764-1993

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Combined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6M
NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI094189NIAID NIH HHS UM1 AI126603NIAID NIH HHS UM1 AI126611NIAID NIH HHS UM1 AI126620
6 · The paper itself

Abstract

The latent reservoir of HIV-1 in resting CD4

Indexed as

Immunologic MemoryAdultCD4-Positive T-LymphocytesCell DifferentiationCell ProliferationDNA, ViralGene Expression Regulation, ViralHIV-1HumansLymphocyte ActivationLymphocyte CountPhenotypePhylogenyProvirusesT-Lymphocyte SubsetsTranscription, GeneticDNA, Viral

Identifiers

PMID31996465
PMCPMC7875249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.