Evidence map›Paper›PMID 31996455›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation in Humans with Tetraplegia.

Francisco D Benavides, Hang Jin Jo, Henrik Lundell, V Reggie Edgerton, Yuri Gerasimenko, Monica A Perez

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06950593 (Upper Limb Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke), which is not on this map. Cited by 86 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 3 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06950593 narecruitingnot on this mapstarted 2025, after this paper: background citation

Upper Limb Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

TypeinterventionalSponsorShirley Ryan AbilityLabRan2025 to 2027Enrolled14ConditionsUpper Limb Hemiparesis Following StrokeArmsTask Specific Training (TST), Transcutaneous electrical spinal cord stimulation (TESS), Sham transcutaneous electrical spinal cord stimulation (Sham TESS)
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 5 countries.

Francisco D BenavidesDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami, Miami VA Medical Center, Miami, Florida 33136.
Hang Jin JoDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami, Miami VA Medical Center, Miami, Florida 33136.
Henrik LundellDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, Denmark.
V Reggie EdgertonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095-7246.
Yuri GerasimenkoPavlov Institute of Physiology, St. Petersburg 197022, Russia.ORCID 0000-0002-9345-3791
Monica A PerezDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami, Miami VA Medical Center, Miami, Florida 33136, mperez04@sralab.org.
Northwestern University · USHvidovre Hospital · DKUniversity of Louisville · USUniversity of Technology Sydney · AU

Funding

Corticospinal Function after Spinal Cord InjuryR01NS090622 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEREZ, MONICA A · 2014 to 2018
$1.6M
NINDS NIH HHS R01 NS090622
6 · The paper itself

Abstract

An increasing number of studies supports the view that transcutaneous electrical stimulation of the spinal cord (TESS) promotes functional recovery in humans with spinal cord injury (SCI). However, the neural mechanisms contributing to these effects remain poorly understood. Here we examined motor-evoked potentials in arm muscles elicited by cortical and subcortical stimulation of corticospinal axons before and after 20 min of TESS (30 Hz pulses with a 5 kHz carrier frequency) and sham-TESS applied between C5 and C6 spinous processes in males and females with and without chronic incomplete cervical SCI. The amplitude of subcortical, but not cortical, motor-evoked potentials increased in proximal and distal arm muscles for 75 min after TESS, but not sham-TESS, in control subjects and SCI participants, suggesting a subcortical origin for these effects. Intracortical inhibition, elicited by paired stimuli, increased after TESS in both groups. When TESS was applied without the 5 kHz carrier frequency both subcortical and cortical motor-evoked potentials were facilitated without changing intracortical inhibition, suggesting that the 5 kHz carrier frequency contributed to the cortical inhibitory effects. Hand and arm function improved largely when TESS was used with, compared with without, the 5 kHz carrier frequency. These novel observations demonstrate that TESS influences cortical and spinal networks, having an excitatory effect at the spinal level and an inhibitory effect at the cortical level. We hypothesized that these parallel effects contribute to further the recovery of limb function following SCI.

Indexed as

AdultCerebral CortexCervical CordElectromyographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexNeuronal PlasticityQuadriplegiaRecovery of FunctionSpinal Cord InjuriesSpinal Cord StimulationYoung Adultcorticospinalintracortical inhibitionneurophysiologyneuroplasticityspinal cord injuryspinal networks

Identifiers

PMID31996455
PMCPMC7096150
OpenAlexW3004094941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.