Evidence map›Paper›PMID 31996452›Full record

SynthesisNeurology2020

Seizure outcome of pediatric epilepsy surgery: Systematic review and meta-analyses.

Elysa Widjaja, Puneet Jain, Lindsay Demoe, Astrid Guttmann, George Tomlinson, Beate Sander

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Is intraoperative electrocorticography (ECoG) for long-term epilepsy-associated tumors (LEATs) more useful in children?-A Randomized Controlled Trial.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Trial
  6. Trial
  7. Article
  8. Article
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  11. Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Frontiers in medicine · 2026
    Article
  18. Article
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  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elysa WidjajaFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada. Elysa.Widjaja@sickkids.ca.ORCID 0000-0003-0986-5476
Puneet JainFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada.
Lindsay DemoeFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada.
Astrid GuttmannFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada.ORCID 0000-0001-8177-2253
George TomlinsonFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada.
Beate SanderFrom the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.S.), University of Toronto, ON, Canada; Diagnostic Imaging (E.W.); Division of Neurology (E.W., P.J.); Neuroscience and Mental Health (L.D.), Hospital for Sick Children, Toronto; ICES (A.G., B.S.), Toronto, ON, Canada; Department of Pediatrics (A.G.), Hospital for Sick Children, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.S.), University Health Network, Toronto, ON, Canada; and Public Health Ontario (B.S.), Toronto, ON, Canada.ORCID 0000-0003-2128-9133
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review and meta-analyses assessed seizure outcome following pediatric epilepsy surgery.

methodsMEDLINE, EMBASE, and Cochrane were searched for pediatric epilepsy surgery original research from 1990 to 2017. The outcome was seizure freedom at 12 months or longer follow-up. Using random-effects models, the effect sizes for controlled studies, uncontrolled studies on surgery locations (temporal lobe [TL], extratemporal lobe [ETL], or hemispheric surgery), pathologies, nonlesional epilepsy, and incomplete resection were estimated. Meta-regression assessed the relationship between age at surgery, age at seizure onset, and seizure outcome. Random-effects network meta-analysis was conducted for surgery locations.

resultsTwo hundred fifty-eight studies were included. Surgery achieved higher seizure freedom than medical therapy (odds ratio [OR] = 6.49 [95% confidence interval [CI]: 2.87-14.70],

conclusionEpilepsy surgery was more effective than medical therapy to control seizures. Understanding seizure outcomes of different surgery locations, pathologies, nonlesional epilepsy, and incomplete resection will assist with presurgical counseling.

Indexed as

ChildEpilepsyHumansSeizuresTreatment Outcome

Identifiers

PMID31996452
OpenAlexW3003689867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.