ArticleNeurology2020
Anatomical evidence of an indirect pathway for word repetition.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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49citing papers in PubMed, 3 pooled it
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49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
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- Neural structures associated with auditory short-term memory and sentence repetition following chronic left hemisphere stroke.Frontiers in neuroscience · 2026Article
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- Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus.Communications biology · 2024Article
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- Wernicke's functional neuroanatomy model of language turns 150: what became of its psychological reflex arcs?Brain structure & function · 2024Review
- On the role of the arcuate fasciculus in word production and repetition: a reply to Van den Hoven et al. (2024).Brain structure & function · 2024Article
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Authors and funding
11 authors at 1 institution in 2 countries.
Stephanie J ForkelFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0003-0493-0283
Emily RogalskiFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0002-6472-1363
Niki Drossinos SanchoFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.
Lucio D'AnnaFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.
Pedro Luque LagunaFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.
Jaiashre SridharFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.
Flavio Dell'AcquaFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0001-5313-5476
Sandra WeintraubFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0003-2605-5205
Cynthia ThompsonFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0003-3718-7545
M-Marsel MesulamFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL.ORCID 0000-0001-5731-851X
Marco CataniFrom the Departments of Neuroimaging and Forensic and Neurodevelopmental Sciences (S.J.F., N.D.S., L.D., P.L.L., F.D., M.C.), Natbrainlab, Sackler Institute of Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mesulam Center for Cognitive Neurology and Alzheimer's Disease (E.R., J.S., S.W., M.-M.M.), Department of Psychiatry and Behavioral Sciences (E.R.), and Department of Neurology (M.M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Neuroscience and Experimental Psychology, School of Biological Sciences (N.D.S., S.W.), University of Manchester, UK; and Neurobiology of Language Recovery, Aphasia and Neurolinguistics Research Laboratory, Communication Sciences and Disorders, and Neurology (C.T.), Northwestern University, Chicago, IL. m.catani@iop.kcl.ac.uk.ORCID 0000-0002-5488-6463
Northwestern University · US
Funding
Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9MLanguage in Primary Progressive AphasiaR01DC008552 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MESULAM, MAREK-MARSEL M · 2007 to 2021
$8.5MDeterminants of neurodegenerative decline in the aphasic variant of Alzheimer's diseaseR01AG056258 · NIA · UNIVERSITY OF CHICAGO · PI ROGALSKI, EMILY J · 2017 to 2022
$4.1MDeterminants of Neurodegenerative Decline in Primary Progressive AphasiaR01NS075075 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROGALSKI, EMILY J · 2012 to 2016
$1.7MNIA NIH HHS P30 AG013854NIA NIH HHS R01 AG056258NIDCD NIH HHS R01 DC008552NINDS NIH HHS R01 NS075075Wellcome Trust
Abstract
objectiveTo combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA).
methodsThe traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways.
resultsCompared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway.
conclusionsThe results suggest that in PPA, deficits in repetition are due to damage to the temporo-parietal cortex and its connections to Wernicke and Broca regions. We therefore propose a revised language model that also includes an indirect pathway for repetition, which has important clinical implications for the functional mapping and treatment of neurologic patients.
Indexed as
AgedAphasia, Primary ProgressiveBroca AreaCase-Control StudiesCerebral CortexDiffusion Tensor ImagingFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysOrgan SizeParietal LobeWernicke Area
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