Evidence map›Paper›PMID 31996427›Full record

ArticleJournal of virology2020

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.

Siaw Shi Boon, Chichao Xia, Jin Yan Lim, Zigui Chen, Priscilla T Y Law, Apple C M Yeung, Miranda Thomas, Lawrence Banks, Paul K S Chan

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Siaw Shi BoonDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.
Chichao XiaDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.
Jin Yan LimDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.
Zigui ChenDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.ORCID 0000-0002-8577-1298
Priscilla T Y LawDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.
Apple C M YeungDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR.
Miranda ThomasInternational Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Lawrence BanksInternational Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Paul K S ChanDepartment of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR paulkschan@cuhk.edu.hk.
Chinese University of Hong Kong · HKInternational Centre for Genetic Engineering and Biotechnology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) type 58 is the third most commonly detected HPV type in cervical cancer among Eastern Asians. Our previous international epidemiological studies revealed that HPV58 carrying an E7 natural variant, T20I/G63S (designated V1), was associated with a higher risk of cervical cancer. We recently showed that V1 possesses a greater ability to immortalize and transform primary cells, as well as degrading pRB more effectively, than the prototype and other common variants. In this study, we performed a series of phenotypic and molecular assays using physiologically relevant

Indexed as

AnimalsAsian PeopleCell ProliferationDisease Models, AnimalFemaleGenetic VariationHumansMiceMice, NudeOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesRatsUterine Cervical NeoplasmsOncogene Proteins, ViralPapillomavirus VaccinesHPV58E7oncogenicityT20I/G63SV1

Identifiers

PMID31996427
PMCPMC7108839
OpenAlexW3003863486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.