Evidence map›Paper›PMID 31996326›Full record

ReviewAgeing research reviews2020

Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.

Richard D Semba, Qu Tian, Michelle C Carlson, Qian-Li Xue, Luigi Ferrucci

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Article
  8. Article
  9. Adolescent IQ and performance-based measures of physical function in old age: a 54-year longitudinal study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  10. Article
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  16. Healthy Behavior for Preventing Cognitive Disability in Older Persons.International journal of environmental research and public health · 2025
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rdsemba@jhmi.edu.
Qu TianNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Michelle C CarlsonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Qian-Li XueDepartments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Johns Hopkins University · USNational Institute on Aging · US

Funding

Oxidative stress and the pathogenesis of sarcopenia and disability in older womenR01AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2005 to 2018
$3.6M
Systemic rejuvenating factors and human aging phenotypes.R01AG057723 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2018 to 2022
$1.8M
Systemic complement and age-related macular degeneration.R01EY024596 · NEI · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2014 to 2016
$1.6M
Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older WomenR56AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2008 to 2008
$391k
Relationship of candidate circulating proteoforms with aging phenotypes.R56AG052973 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2016 to 2016
$211k
NEI NIH HHS R01 EY024596NIA NIH HHS R01 AG027012NIA NIH HHS R01 AG057723NIA NIH HHS R56 AG027012NIA NIH HHS R56 AG052973
6 · The paper itself

Abstract

Dementia is characterized by a long preclinical phase that may last years to decades before the onset of mild cognitive impairment. Slow gait speed and subjective memory complaint commonly co-occur during this preclinical phase, and each is a strong independent predictor of cognitive decline and dementia. Motoric cognitive risk (MCR) syndrome is a pre-dementia syndrome that combines these two early harbingers of dementia. The risk of cognitive decline or dementia is stronger for MCR than for either slow gait speed or subjective memory complaint alone. Slow gait speed and subjective memory complaint have several common risk factors: cardiovascular disease, diabetes mellitus, abnormal cortisol profiles, low vitamin D levels, brain atrophy with decreased hippocampal volume, and increased deposition of beta-amyloid in the brain. The underlying pathogenesis of MCR remains poorly understood. Metabolomics and proteomics have great potential to provide new insights into biological pathways involved in MCR during the long preclinical phase preceding dementia.

Indexed as

Cognition DisordersCognitive DysfunctionDementiaAgedCognitionGaitHumansNeuropsychological TestsRisk FactorsAlzheimer’s diseaseCognitive declineDementiaGaitMemorySkeletal muscle

Identifiers

PMID31996326
PMCPMC7697173
OpenAlexW3002484752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.