Evidence map›Paper›PMID 31996155›Full record

ArticleBMC pregnancy and childbirth2020

Successful monozygotic triplet pregnancy after a single blastocyst transfer following in vitro maturation of oocytes from a woman with polycystic ovary syndrome: a case report.

Kuniaki Ota, Toshifumi Takahashi, Mikiko Katagiri, Ryu Matsuoka, Akihiko Sekizawa, Hideki Mizunuma, Hiroaki Yoshida

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kuniaki OtaFukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Toshifumi TakahashiFukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan. totakaha@fmu.ac.jp.ORCID http://orcid.org/0000-0003-0955-4248
Mikiko KatagiriSendai ART Clinic, 206-13 Nagakecho, Miyagino, Sendai, Myagi, 983-0864, Japan.
Ryu MatsuokaDepartment of obstetrics and gynecology, Showa University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Akihiko SekizawaDepartment of obstetrics and gynecology, Showa University, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Hideki MizunumaFukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Hiroaki YoshidaSendai ART Clinic, 206-13 Nagakecho, Miyagino, Sendai, Myagi, 983-0864, Japan.
Fukushima Medical University · JPSendai Medical Center · JPShowa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough women with polycystic ovarian syndrome (PCOS)-related sub-fertility are high responders to controlled ovarian stimulation, it is difficult to obtain mature oocytes in these women. Therefore, in vitro maturation (IVM), which is the technique of letting the contents of the ovarian follicles and the oocytes inside mature in vitro, has often been proposed in such women. We describe the first successful delivery of monozygotic triplets resulting from transfer of a single blastocyst following IVM of oocytes. CASE PRESENTATION: A 32-year-old nulligravida female with PCOS underwent IVM. She underwent vitrified-warmed single blastocyst transfer following IVM, and a dichorionic triamniotic triplet pregnancy was confirmed at 8 weeks. Healthy triplets were delivered by cesarean section at 33 weeks' gestation. This is the first case of monozygotic triplets derived from IVM oocytes that were successfully delivered. The determination of chorionicity and amnionicity is generally supposed until 3 days after fertilization, and no division or splitting of her embryo was observed on transfer. Interestingly, her embryo might have split after the transfer, resulting in a dichorionic triamniotic triplet pregnancy.

conclusionsPatients should be informed of a possible increased risk of monozygotic multiple pregnancies after single embryo transfer following IVM.

Indexed as

In Vitro Oocyte Maturation TechniquesPregnancy OutcomePregnancy, TripletAdultEmbryo TransferFemaleHumansInfertility, FemalePolycystic Ovary SyndromePregnancyTissue and Organ HarvestingAssisted reproductive technologyIn vitro maturation of oocyte, monozygotic triplets, polycystic ovary syndromeZygotic splitting

Identifiers

PMID31996155
PMCPMC6988260
OpenAlexW3005785289

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.