Observational studyBMC neurology2020
Advanced ultrasound methods in assessment of carotid plaque instability: a prospective multimodal study.
Observational study in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Diagnostic Performance of Deep Learning and Radiomics in Extracranial Carotid Plaque Detection: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Current status and advances in ultrasound evaluation of neovascularization within carotid artery plaques: a systematic review.Cardiovascular ultrasound · 2025Pooled it
- Ultrasound biomechanical indices in carotid artery disease: evaluation of shear modulus, circumferential stress, longitudinal stress, and stiffness index-a cross-sectional study.Scientific reports · 2026Article
- Review
- Burden of Cardiovascular Diseases Attributable to Hypertension in Population Aged 60 Years or Older from 1990 to 2040 across BRICS-plus Countries (Egypt, Ethiopia, Iran, Saudi Arabia, United Arab Emirates, Brazil, Russia, India, China, and South Africa).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Establishment and validation of a risk prediction model for acute ischemic stroke in a carotid artery plaque population.Quantitative imaging in medicine and surgery · 2025Article
- Plaque biomarkers from high-frame rate vector flow imaging and shear wave elastography in mild carotid stenosis.Ultrasonography (Seoul, Korea) · 2025Article
- Carotid artery hemodynamics and geometry as predictors of cerebral small vessel disease: insights from 4D flow imaging.Neuroradiology · 2025Article
- The hemodynamic and geometric characteristics of carotid artery atherosclerotic plaque formation.Quantitative imaging in medicine and surgery · 2024Article
- Advances in Clinical Imaging of Vascular Inflammation: A State-of-the-Art Review.JACC. Basic to translational science · 2024Review
- Interleukin-6 and thyroid-stimulating hormone index predict plaque stability in carotid artery stenosis: analyses by lasso-logistic regression.Frontiers in cardiovascular medicine · 2024Article
- Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability-Narrative Review.Journal of clinical medicine · 2023Review
- Effects of norepinephrine on plaque hypoxia in atherosclerotic rabbits.Frontiers in cardiovascular medicine · 2023Article
- Article
- The Predictive Value of Contrast-Enhanced Ultrasound Combined with Serum miR-124 Level in Acute Cerebral Infarction and Their Correlation with the Contrast Enhancement of Carotid Atherosclerotic Plaque.Neuropsychiatric disease and treatment · 2022Article
- Identification of Biomarkers of Autophagy-Related Genes Between Early and Advanced Carotid Atherosclerosis.International journal of general medicine · 2022Article
- Hypothesis of "stroke-stop" formula: a tool for risk index determination in development of acute cerebrovascular disease in asymptomatic individuals with carotid stenosis.BMC neurology · 2021Article
- Studying the Factors of Human Carotid Atherosclerotic Plaque Rupture, by Calculating Stress/Strain in the Plaque, Based on CEUS Images: A Numerical Study.Frontiers in neuroinformatics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA significant proportion of ischemic strokes are caused by emboli from atherosclerotic, unstable carotid artery plaques. The selection of patients for endarterectomy in current clinical practice is primarily based on the degree of carotid artery stenosis and clinical symptoms. However, the content of the plaque is known to be more important for stroke risk. Intraplaque neovascularization (IPN) has recently emerged as a possible surrogate marker for plaque instability. Neo-microvessels from the adventitial vasa vasorum grow into the full thickness of the vessel wall in an adaptive response to hypoxia, causing subsequent intraplaque haemorrhage and plaque rupture. Conventional ultrasound cannot detect IPN. Contrast-enhanced ultrasound and Superb Microvascular Imaging (SMI), have, however, shown promise in IPN assessment. Recent research using Shear Wave Elastography (SWE) has also reported reduced tissue stiffness in the artery wall (reduced mean Young's modulus) in unstable compared to stable plaques. The purpose of this study is to identify unstable carotid artery plaques at risk of rupture and future ischemic stroke risk using multimodal assessments.
methodsForty five symptomatic and 45 asymptomatic patients > 18 years, with > 50% carotid stenosis referred to Oslo University Hospital ultrasound lab will be included in this on-going project. Patients will undergo contrast enhanced ultrasound, SMI, carotid-MRI and PET-( DISCUSSION: This multimodality study will primarily provide information on the clinical value of advanced ultrasound methods (SMI, SWE) for the detection of unstable carotid artery plaque in comparison with other methods including contrast-enhanced ultrasound, carotid-MRI and PET-(
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.