Evidence map›Paper›PMID 31996027›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Hematopoietic Cell-Expressed Endothelial Nitric Oxide Protects the Liver From Insulin Resistance.

Brian P Dick, Ryan McMahan, Taft Knowles, Lev Becker, Sina A Gharib, Tomas Vaisar, Tomasz Wietecha, Kevin D O'Brien, Karin E Bornfeldt, Alan Chait and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Brian P DickFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Ryan McMahanFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Taft KnowlesFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Lev BeckerBen May Department for Cancer Research, University of Chicago, IL (L.B.).
Sina A GharibFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Tomas VaisarFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Tomasz WietechaFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Kevin D O'BrienFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Karin E BornfeldtFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Alan ChaitFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
Francis KimFrom the Department of Medicine, University of Washington, Seattle (B.P.D., R.M., T.K., S.A.G., T.V., T.W., K.D.O., K.E.B., A.C., F.K.).
University of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2008 to 2019
$23.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
Integrated Multi-omics of MelioidosisR01AI137111 · NIAID · UNIVERSITY OF WASHINGTON · PI GHARIB, SINA A, WEST, TIMOTHY EOIN · 2018 to 2021
$3.2M
Red Blood Cell Endothelial Nitric Oxide Attenuates Insulin ResistanceR01HL139555 · NHLBI · UNIVERSITY OF WASHINGTON · PI KIM, FRANCIS · 2018 to 2021
$2.2M
Proteolytic control of local inflammatory macrophage proliferationR01HL127694 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2015 to 2018
$2.0M
Endothelial nitric oxide synthase and regulation of macrophage functionR01DK106703 · NIDDK · UNIVERSITY OF WASHINGTON · PI KIM, FRANCIS · 2016 to 2019
$1.8M
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS R01 HL127694NHLBI NIH HHS R01 HL139555NIAID NIH HHS R01 AI137111NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK106703
6 · The paper itself

Abstract

objectiveMice genetically deficient in endothelial nitric oxide synthase (Nos3

conclusionsThese results would suggest that the metabolic and hepatic consequences of high-fat feeding are mediated by loss of Nos3/nitric oxide actions in bone marrow-derived cells, not in endothelial cells.

Indexed as

Energy MetabolismInsulin ResistanceAnimalsBlood GlucoseBone Marrow TransplantationDiet, Fat-RestrictedDiet, High-FatDisease Models, AnimalEndothelial CellsInflammation MediatorsLiverMacrophagesMaleMice, Inbred C57BLMice, KnockoutNitric OxideBlood GlucoseInflammation MediatorsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseendothelial cellsinsulin resistancemacrophagenitric oxide

Identifiers

PMID31996027
PMCPMC7047596
OpenAlexW3003534805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.