ArticleKidney research and clinical practice2020
Association of hypoalbuminemia with short-term and long-term mortality in patients undergoing continuous renal replacement therapy.
Article in Kidney research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Pooled it
- Associations between blood cell-based inflammatory indices and their changes and mortality in patients undergoing transcatheter aortic valve replacement: a retrospective investigation with prospective multicenter cohort validation study.International journal of surgery (London, England) · 2025Article
- Age-stratified mortality and associated risk factors in adults aged 65 years or older undergoing continuous kidney replacement therapy: a consecutive retrospective study.BMC nephrology · 2025Article
- A higher prognostic nutritional index is inversely associated with the need for renal replacement therapy in elderly critically Ill surgical patients.BMC surgery · 2025Article
- Impact of the prognostic nutritional index on renal replacement therapy-free survival and mortality in patients on continuous renal replacement therapy.Renal failure · 2024Article
- Biomarkers to predict mortality in patients with Fournier's gangrene admitted to the intensive care unit after surgery in South Korea.Acute and critical care · 2023Article
- Hospital mortality and prognostic factors in critically ill patients with acute kidney injury and cancer undergoing continuous renal replacement therapy.Kidney research and clinical practice · 2022Article
- Worsening or improving hypoalbuminemia during continuous renal replacement therapy is predictive of patient outcome: a single-center retrospective study.Journal of intensive care · 2022Article
- Assessment of Risk Factors for Mortality in Patients in Medical Intensive Care Unit of a Tertiary Hospital.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Reduced serum albumin as a risk factor for poor prognosis in critically ill patients receiving renal replacement therapy.BMC nephrology · 2021Article
- Effect of Phoxilium on prognostic predictors in patients undergoing continuous venovenous hemodiafiltration.Kidney research and clinical practice · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoalbuminemia reflects several pathological conditions, including nutritional deficiencies and chronic inflammation. However, its relationship with short-term and long-term mortality in patients undergoing continuous renal replacement therapy (CRRT) remains unclear. The present study aimed to assess the effect of hypoalbuminemia on mortality in a large cohort of patients undergoing CRRT.
methodsThe study retrospectively reviewed 1,581 patients who underwent CRRT for the treatment of acute kidney injury from 2010 to 2016. The patients were categorized by tertiles of serum albumin levels at CRRT initiation. The odds ratios and hazard ratios for the risk of all-cause mortality were calculated before and after adjustment for multiple covariates.
resultsThe mean albumin level was 2.7 ± 0.6 g/dL at CRRT initiation. During a median follow-up period of 14 days (maximum, 4 years), 1,040 patients (65.8%) died. The risk of overall mortality was higher in the first tertile group than in the third tertile group (hazard ratio, 1.9 [1.63-2.21]). When the mortality rate was stratified by timeframe, the risk was steadily higher in the first tertile group than in the third tertile group (odds ratios: 3.0 [2.34-3.87] for 2-week mortality, 2.7 [2.12-3.52] for 1-month mortality, 2.7 [2.08-3.53] for 6-month mortality, and 2.8 [2.11-3.62] for 1-year mortality). Additionally, the rates of intensive care unit mortality and in-hospital mortality were higher in the first tertile group than in the third tertile group.
conclusionThe initial hypoalbuminemia was independently associated with short-term and long-term mortality in patients undergoing CRRT. Thus, the serum albumin level should be monitored during CRRT.
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