Evidence map›Paper›PMID 31995668›Full record

Observational studyPediatric pulmonology2020

Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease.

Judith A Voynow, Kimberley Fisher, Mary E Sunday, Charles M Cotten, Aaron Hamvas, Karen D Hendricks-Muñoz, Brenda B Poindexter, Gloria S Pryhuber, Clement L Ren, Rita M Ryan and 6 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01435187 (Prematurity and Respiratory Outcomes Program), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01435187 completednot on this map

Prematurity and Respiratory Outcomes Program (PROP) Core Database Protocol

TypeobservationalSponsorUniversity of PennsylvaniaRan2011 to 2016Enrolled835ConditionsPrematurity, Respiratory Disease
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Eight practices for data management to enable team data science.Journal of clinical and translational science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Judith A VoynowDivision of Pediatric Pulmonology, Duke University, Durham, North Carolina.ORCID 0000-0002-2437-2859
Kimberley FisherDivision of Neonatology, Duke University, Durham, North Carolina.
Mary E SundayDepartment of Pathology, Duke University, Durham, North Carolina.
Charles M CottenDivision of Neonatology, Duke University, Durham, North Carolina.
Aaron HamvasDivision of Neonatology, Washington University, St Louis, Missouri.
Karen D Hendricks-MuñozDivision of Neonatology, Children's Hospital of Richmond, Richmond, Virginia.ORCID 0000-0002-6367-0373
Brenda B PoindexterDivision of Neonatology, Indiana University, Indianapolis, Indiana.
Gloria S PryhuberUniversity of Rochester, Rochester, New York.
Clement L RenDivision of Pediatric Pulmonology, University of Rochester, Rochester, New York.
Rita M RyanDivision of Neonatology, State University of New York at Buffalo, Buffalo, New York.
Jack K SharpDivision of Pediatric Pulmonology, Duke University, Durham, North Carolina.
Sarah P YoungDivision of Medical Genetics, Duke University, Durham, North Carolina.
Haoyue ZhangDivision of Medical Genetics, Duke University, Durham, North Carolina.
Rachel G GreenbergDivision of Neonatology and The Duke Clinical Research Institute, Duke University, Durham, North Carolina.
Amy H HerringDuke Global Health Institute, Duke University, Durham, North Carolina.
Stephanie D DavisDivision of Pediatric Pulmonology, Indiana University, Indianapolis, Indiana.
Duke University · USUniversity of Rochester · USChildren's Hospital of Richmond at VCU · USIndiana University Health · USMedical University of South Carolina · USNorthwestern University · USUniversity of North Carolina at Chapel Hill · US

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Data Coordinating Center for the Prematurity and Respiratory Outcomes ProgramU01HL101794 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, BARBARA · 2010 to 2014
$10.3M
Gastrin-Releasing Peptide and Bronchopulmonary DysplasiaR01HL105702 · NHLBI · DUKE UNIVERSITY · PI COTTEN, CHARLES MICHAEL, DAVIS, STEPHANIE DUGGINS · 2011 to 2015
$2.8M
Biomarkers of Immunologic Function and Preterm Respiratory OutcomesU01HL101800 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A., JOBE, ALAN H · 2010 to 2014
$2.5M
Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic PreemiesU01HL101813 · NHLBI · UNIVERSITY OF ROCHESTER · PI MARIANI, THOMAS J, PRYHUBER, GLORIA S · 2010 to 2014
$2.4M
Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary DysplasiaU01HL101465 · NHLBI · WASHINGTON UNIVERSITY · PI FERKOL, THOMAS W, WARNER, BARBARA B · 2010 to 2014
$2.1M
NCATS NIH HHS UL1 TR002001NHLBI NIH HHS 5R01 HL105702NHLBI NIH HHS R01 HL105702NHLBI NIH HHS U01 HL101465NHLBI NIH HHS U01 HL101794NHLBI NIH HHS U01 HL101800NHLBI NIH HHS U01 HL101813
6 · The paper itself

Abstract

rationaleBronchopulmonary dysplasia (BPD) is associated with post-prematurity respiratory disease (PRD) in survivors of extreme preterm birth. Identifying early biomarkers that correlate with later development of BPD and PRD may provide insights for intervention. In a preterm baboon model, elevated gastrin-releasing peptide (GRP) is associated with BPD, and GRP inhibition mitigates BPD occurrence.

objectiveWe performed a prospective cohort study to investigate whether urine GRP levels obtained in the first postnatal week were associated with BPD, PRD, and other urinary biomarkers of oxidative stress.

methodsExtremely low gestational age infants (23-28 completed weeks) were enrolled in a US multicenter observational study, The Prematurity and Respiratory Outcomes Program (http://clinicaltrials.gov/ct2/show/NCT01435187). We used multivariable logistic regression to examine the association between urine GRP in the first postnatal week and multiple respiratory outcomes: BPD, defined as supplemental oxygen use at 36 + 0 weeks postmenstrual age, and post-PRD, defined by positive quarterly surveys for increased medical utilization over the first year (PRD score).

resultsA total of 109 of 257 (42%) infants had BPD, and 120 of 217 (55%) had PRD. On adjusted analysis, GRP level more than 80 was associated with BPD (adjusted odds ratio [aOR], 1.83; 95% confidence interval [CI], 1.03-3.25) and positive PRD score (aOR, 2.46; 95% CI, 1.35-4.48). Urine GRP levels correlated with duration of NICU ventilatory and oxygen support and with biomarkers of oxidative stress: allantoin and 8-hydroxydeoxyguanosine.

conclusionsUrine GRP in the first postnatal week was associated with concurrent urine biomarkers of oxidative stress and with later diagnoses of BPD and PRD.

Indexed as

Infant, Extremely PrematureBiomarkersBronchopulmonary DysplasiaFemaleGastrin-Releasing PeptideHumansInfant, NewbornInfant, Premature, DiseasesLogistic ModelsMaleProspective StudiesRespiration DisordersRespiratory Tract DiseasesBiomarkersGastrin-Releasing Peptidebronchopulmonary dysplasiagastrin-releasing peptidereactive oxygen species

Identifiers

PMID31995668
PMCPMC7071969
OpenAlexW3004241515

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.