ArticleDepression and anxiety2020
Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression.
Article in Depression and anxiety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Inflammation as a mediating pathway between social defeat and mental health in humans: A systematic review.Translational psychiatry · 2026Pooled it
- Why do adolescents attempt suicide? Insights from leading ideation-to-action suicide theories: a systematic review.Translational psychiatry · 2024Pooled it
- A systematic review of associations between emotion regulation characteristics and inflammation.Neuroscience and biobehavioral reviews · 2023Pooled it
- Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.JAMA psychiatry · 2020Pooled it
- Pro-inflammatory markers interact with spontaneous theta oscillations to predict depression among adolescents.Brain, behavior, and immunity · 2026Article
- Stressful life events and lifestyle factors are associated with elevated peripheral TNF-α levels in adults with depression without physical diseases.European archives of psychiatry and clinical neuroscience · 2026Article
- Six New Phenolic Compounds in Ethyl Acetate Extract of Tall Gastrodia Tuber (Tianma) with Four Compounds Screened Preliminarily for Cytoprotective Effects Against Excitotoxicity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Early life stress enhances the association between residential nature exposure and fasting blood glucose.PloS one · 2026Article
- Circulating cell-free mitochondrial DNA as a candidate marker of hyperinflammation and immune activation in pre-adolescents, adolescents and young adults with COVID-19 and comorbidities.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months.Development and psychopathology · 2025Article
- Interplay between Stressful Life Events and Interleukin-1β on 12-week Antidepressant Response in Depressive Patients.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Protocol for project MHISS: Mental Health and Immunodynamics of Social Stress.Brain, behavior, & immunity - health · 2025Article
- Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program.Brain, behavior, and immunity · 2025Observational
- Risk for Depressive Symptoms Among Adolescents with a History of Adversity: Unique Role of Stress Appraisals.Child psychiatry and human development · 2025Article
- Reactivity to Peer Rejection Moderates the Effect of Victimization on Adolescent Girls' Depressive Symptoms: A Prospective Study.Research on child and adolescent psychopathology · 2024Article
- School Bullying Victimization and Depression Symptoms in Adolescents: The Mediating Role of Internet Addiction and Moderating Role of Living Areas.The Psychiatric quarterly · 2024Article
- Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.bioRxiv : the preprint server for biology · 2024Article
- The Interplay of Peer Victimization and Parasympathetic Nervous System Activity on Acute Inflammatory Stress Responses in Adolescence.Research on child and adolescent psychopathology · 2024Article
- Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Sex Differences in Stress Susceptibility as a Key Mechanism Underlying Depression Risk.Current psychiatry reports · 2024Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDepression rates increase markedly for girls across the adolescent transition, but the social-environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which posits that individuals who mount stronger inflammatory responses to social stress should exhibit greater increases in depressive symptoms following interpersonal life stress exposure than those who mount weaker inflammatory responses to such stress.
methodParticipants were 116 adolescent girls (M
resultsAs hypothesized, greater interpersonal life stress exposure was associated with significant increases in depression over time, but only for girls exhibiting stronger salivary tumor necrosis factor-α and interleukin-1β reactivity to social stress. In contrast, noninterpersonal stress exposure was unrelated to changes in depression longitudinally, both alone and when combined with youths' cytokine reactivity scores. DISCUSSION: These results are consistent with Social Signal Transduction Theory of Depression and suggest that heightened inflammatory reactivity to social stress may increase adolescents' risk for depression. Consequently, it may be possible to reduce depression risk by modifying inflammatory responses to social stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.