Trial reportPloS one2020
Preconception nutrition intervention improved birth length and reduced stunting and wasting in newborns in South Asia: The Women First Randomized Controlled Trial.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Women First: Preconception Maternal Nutrition
DEUX OEUFs:Cracking the Potential of Eggs to Improve Child Growth and Development
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effectiveness of digital health in improving pregnancy quality among preconception women: A systematic review.Narra J · 2025Pooled it
- Effect of preconception multiple micronutrients vs. iron-folic acid supplementation on maternal and birth outcomes among women from developing countries: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Trial
- Hemoglobin During Pregnancy Does Not Mediate the Relationship between Nutrition Supplements and Intrauterine Growth: A Secondary Data Analysis of Women First Preconception Nutrition Trial.The Journal of nutrition · 2025Trial
- Preconception Micronutrient Supplementation Affects Maternal BMI and Body Composition Postpartum: A Randomized Controlled Trial in Vietnam.The Journal of nutrition · 2024Trial
- Preconception micronutrient supplementation positively affects child intellectual functioning at 6 y of age: A randomized controlled trial in Vietnam.The American journal of clinical nutrition · 2021Trial
- Maternal Characteristics Affect Fetal Growth Response in the Women First Preconception Nutrition Trial.Nutrients · 2019Trial
- Article
- Bridging the gaps: advancing preconception nutrition in South Asia through evidence, policy, and action.The Lancet regional health. Southeast Asia · 2025Review
- Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review.The Lancet regional health. Southeast Asia · 2025Review
- Policies and programmes to improve preconception nutrition in South Asia.The Lancet regional health. Southeast Asia · 2025Review
- Effect of Preconception Care on Anemia and Body Mass Index among Women in a Rural and Tribal Area, Nashik District, India.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Influence of Socioeconomic Factors and Nutritional Advice on Diet Quality in Women of Reproductive Age: A FIGO-DQS Assessment.Nutrients · 2024Article
- Implementation of preconception care for preventing adverse pregnancy outcomes in rural and tribal areas of Nashik District, India.Preventive medicine reports · 2024Article
- Stunting in the first year of life: Pathway analysis of a birth cohort.PLOS global public health · 2024Article
- Article
- The why, what and how of preconception care: an exploratory descriptive qualitative study in Karnataka, India.Archives of public health = Archives belges de sante publique · 2023Article
- Pre-pregnancy Diet to Maternal and Child Health Outcome: A Scoping Review of Current Evidence.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2023Article
- Birth length is the strongest predictor of linear growth status and stunting in the first 2 years of life after a preconception maternal nutrition intervention: the children of the Women First trial.The American journal of clinical nutrition · 2022Article
- Socio-economic and socio-demographic determinants of diet diversity among rural pregnant women from Pune, India.BMC nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 3 countries.
Funding
Abstract
South Asia has >50% of the global burden of low birth weight (LBW). The objective was to determine the extent to which maternal nutrition interventions commenced before conception or in the 1st trimester improved fetal growth in this region. This was a secondary analysis of combined newborn anthropometric data for the South Asian sites (India and Pakistan) in the Women First Preconception Maternal Nutrition Trial. Participants were 972 newborn of mothers who were poor, rural, unselected on basis of nutritional status, and had been randomized to receive a daily lipid-based micronutrient supplement commencing ≥3 months prior to conception (Arm 1), in the 1st trimester (Arm 2), or not at all (Arm 3). An additional protein-energy supplement was provided if BMI <20 kg/m2 or gestational weight gain was less than guidelines. Gestational age was established in the 1st trimester and newborn anthropometry obtained <48-hours post-delivery. Mean differences at birth between Arm 1 vs. 3 were length +5.3mm and weight +89g. Effect sizes (ES) and relative risks (RR) with 95% CI for Arm 1 vs. 3 were: length-for-age Z-score (LAZ) +0.29 (0.11-0.46, p = 0.0011); weight-for-age Z-score (WAZ) +0.22 (0.07-0.37, p = 0.0043); weight-to-length-ratio-for-age Z-score (WLRAZ) +0.27 (0.06-0.48, p = 0.0133); LAZ<-2, 0.56 (0.38-0.82, p = 0.0032); WAZ <-2, 0.68 (0.53-0.88, p = 0.0028); WLRAZ <-2, 0.76 (0.64-0.89, p = 0.0011); small-for-gestational-age (SGA), 0.74 (0.66-0.83, p<0.0001); low birth weight 0.81 (0.66-1.00, p = 0.0461). For Arm 2 vs. 3, LAZ, 0.21 (0.04-0.38); WAZ <-2, 0.70 (0.53-0.92); and SGA, 0.88 (0.79-0.97) were only marginally different. ES or RR did not differ for preterm birth for either Arm 1 vs. 3 or 2 vs. 3. In conclusion, point estimates for both continuous and binary anthropometric outcomes were consistently more favorable when maternal nutrition supplements were commenced ≥3 months prior to conception indicating benefits to fetal growth of improving women's nutrition in this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.