Evidence map›Paper›PMID 31995375›Full record

ArticleJournal of medicinal chemistry2020

Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.

Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh

Open access · hybridAbstract readVideo-Audio Media
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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  7. Pharmaceuticals (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Gergő DargóDepartment of Chemical and Environmental Process Engineering , Budapest University of Technology and Economics , Műegyetem rakpart 3 , 1111 Budapest , Hungary.
Dávid BajuszMedicinal Chemistry Research Group , Research Centre for Natural Sciences , Magyar tudósok krt. 2 , 1117 Budapest , Hungary.ORCID 0000-0003-4277-9481
Kristóf SimonDepartment of Organic Chemistry and Technology , Budapest University of Technology and Economics , Műegyetem rakpart 3 , 1111 Budapest , Hungary.
Judit MüllerMedicinal Chemistry Laboratory II , Gedeon Richter Plc. , Gyömrői út. 19-21 , 1107 Budapest , Hungary.
György T BaloghDepartment of Chemical and Environmental Process Engineering , Budapest University of Technology and Economics , Műegyetem rakpart 3 , 1111 Budapest , Hungary.ORCID 0000-0001-8273-1760
Gedeon Richter (Hungary) · HUBudapest University of Technology and Economics · HUHUN-REN Research Centre for Natural Sciences · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on p

Indexed as

Binding SitesChemistry, PharmaceuticalDrug DesignHumansHydrogen-Ion ConcentrationMolecular Docking SimulationPharmaceutical PreparationsProtein BindingSerum Albumin, HumanSpectrophotometry, UltravioletTitrimetryPharmaceutical PreparationsSerum Albumin, Human

Identifiers

PMID31995375
PMCPMC7307925
OpenAlexW3003168009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.