ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2020
Mapping pre-dissection aortic wall abnormalities: a multiparametric assessment.
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Predicting curvature evolution on biological surfaces from clinical imaging-derived area dilation: a closed-form interpretable framework.bioRxiv : the preprint server for biology · 2026Article
- Quantifying In Vivo Arterial Deformation from CT and MRI: A Systematic Review of Segmentation, Motion Tracking, and Kinematic Metrics.Bioengineering (Basel, Switzerland) · 2026Review
- Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026Review
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Temporal geometric mapping defines morphoelastic growth model of Type B aortic dissection evolution.Computers in biology and medicine · 2024Article
- Registration-based semi-automatic assessment of aortic diameter growth rate from contrast-enhanced computed tomography outperforms manual quantification.European radiology · 2022Article
- Vascular Deformation Mapping for CT Surveillance of Thoracic Aortic Aneurysm Growth.Radiology · 2022Article
- Imaging surveillance after open aortic repair: a feasibility study of three-dimensional growth mapping.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2021Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesMaximal aortic diameter is commonly used to assess aortic risk but poorly predicts the timing and location of dissection events in patients with connective tissue disease who undergo regular imaging surveillance. Hence, we aimed to use available surveillance computed tomography angiography (CTA) scans to investigate the correlation between 3-dimensional (3D) growth and cyclic transmural wall stress with the location of intimal tear formation.
methodsThree type B aortic dissection patients with 2 available electrocardiogram (ECG)-gated pre-dissection CTA scans and without surgical repair during the pre-dissection interval were retrospectively identified at our institution. Vascular deformation mapping was used to measure 3D aortic growth between 2 pre-dissection clinical CTA studies. In addition, we performed a computational analysis to estimate cyclic transmural wall stress in patient-specific baseline CTA geometries.
resultsIn all 3 connective tissue disease patients, the site of type B aortic intimal tear co-localized with areas of peak 3D aortic wall growth. Aortic growth was detected by clinical radiological assessment in only 1 case. Co-localization of peak transmural stress and the site of intimal tear formation were found in all cases.
conclusionsFocal areas of growth and transmural wall stress co-localized with the site of intimal tear formation. These hypothesis-generating results suggest a possible new analytic pathway for a more sophisticated assessment of the factors leading to the initiation of dissection in patients with connective tissue disease. These methods could improve on current risk-stratification techniques.
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