Evidence map›Paper›PMID 31994605›Full record

ArticleEinstein (Sao Paulo, Brazil)2020

Myelodysplastic syndrome: validation of flow cytometry multilineage score system.

Helena Varela de Araújo, Rodolfo Patussi Correia, Laiz Cameirão Bento, Andressa da Costa Vaz, Flávia Arandas de Sousa, Anderson Marega Alexandre, Daniela Schimidell, Eduardo de Carvalho Pedro, Márcia Regina Ioshida, Rodrigo de Souza Barroso and 1 more

Abstract readValidation Study
In one paragraph

Article in Einstein (Sao Paulo, Brazil), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helena Varela de AraújoCentro de Hematologia de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-1837-5578
Rodolfo Patussi CorreiaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-4117-5988
Laiz Cameirão BentoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2258-4150
Andressa da Costa VazHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-3237-4050
Flávia Arandas de SousaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0484-2315
Anderson Marega AlexandreHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-7922-065X
Daniela SchimidellHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-5011-9681
Eduardo de Carvalho PedroHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-1257-5915
Márcia Regina IoshidaCentro de Hematologia de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-9730-6353
Rodrigo de Souza BarrosoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-7185-4738
Nydia Strachman BacalCentro de Hematologia de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0510-1973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo validate multilineage score system correlating results of flow cytometry, cytogenetics, cytomorphology and histology from samples of patients with suspected myelodysplastic syndrome or cytopenia of unknown origin.

methodsA retrospective study analyzing laboratory data of 49 patients with suspected myelodysplastic syndrome or cytopenia of unknown origin, carried out between May and September 2017. The inclusion criteria were availability of flow cytometry results, and at least one more method, such as morphology, histology or cytogenetics. Thirty-eight patients were classified as diagnosis of myelodysplastic syndromes, whereas 11 were classified as normal. Patients were evaluated based on score systems, Ogata score and flow cytometry multilineage score.

resultsComparing the scores obtained in the Ogata score and the multilineage score, it was observed that in four cases the Ogata score was zero or 1 point, while the multilineage score was higher than 3 points. In addition, in 12 cases with Ogata score of 2, the multilineage score was greater than 3.

conclusionThe flow cytometry multilineage score system demonstrated to be more effective in dysplasia analysis, by assessing the erythroid, monocytic, granulocytic and precursor cell lineages, apart from the parameters evaluated by the Ogata score.

Indexed as

AdolescentAdultAgedAged, 80 and overBiopsyBone Marrow CellsChildChild, PreschoolCytogenetic AnalysisErythroid CellsFemaleFlow CytometryGranulocytesHumansInfantMale

Identifiers

PMID31994605
PMCPMC6986454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.