Evidence map›Paper›PMID 31994309›Full record

Trial reportInfluenza and other respiratory viruses2020

Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus.

Keiko Baba, Ryoko Oka, Shinya Shano, Shinya Omoto, Takeshi Noshi, Takao Shishido, Akira Naito, Keiko Kawaguchi, Toru Ishibashi, Takeki Uehara

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Influenza and other respiratory viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keiko BabaShionogi & Co., Ltd., Osaka, Japan.
Ryoko OkaShionogi & Co., Ltd., Osaka, Japan.
Shinya ShanoShionogi & Co., Ltd., Osaka, Japan.
Shinya OmotoShionogi & Co., Ltd., Osaka, Japan.ORCID 0000-0002-2730-3912
Takeshi NoshiShionogi & Co., Ltd., Osaka, Japan.
Takao ShishidoShionogi & Co., Ltd., Osaka, Japan.ORCID 0000-0002-2549-0945
Akira NaitoShionogi & Co., Ltd., Osaka, Japan.
Keiko KawaguchiShionogi & Co., Ltd., Osaka, Japan.
Toru IshibashiShionogi & Co., Ltd., Osaka, Japan.ORCID 0000-0003-3383-9980
Takeki UeharaShionogi & Co., Ltd., Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug carryover effects have impacts on the observed antiviral effects due to the poor correlation that was observed between viral titer reduction and alleviation of influenza symptoms. Here, we report possible carryover effects of baloxavir acid (BXA), an active form of BXM, on infectious titer testing. Our findings indicate that there is little impact of BXA carryover on the infectious titer testing.

Indexed as

Antiviral AgentsDibenzothiepinsHumansInfluenza, HumanMorpholinesNasopharynxOrthomyxoviridaePharynxPyridonesTriazinesAntiviral AgentsbaloxavirDibenzothiepinsMorpholinesPyridonesTriazinesbaloxavir acidbaloxavir marboxilcap-dependent endonucleasedrug carryoverinfluenza virus

Identifiers

PMID31994309
PMCPMC7182602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.