Evidence map›Paper›PMID 31993926›Full record

ArticleMolecular imaging and biology2020

Type of Anaesthetic Influences [

Anne M Landau, Ove Noer, Aage Kristian Olsen Alstrup, Hélène Audrain, Gregers Wegener, Albert Gjedde, Doris J Doudet, Michael Winterdahl

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anne M LandauDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark. alandau@clin.au.dk.
Ove NoerDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark.
Aage Kristian Olsen AlstrupDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark.
Hélène AudrainDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark.
Gregers WegenerTranslational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
Albert GjeddeDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark.
Doris J DoudetDepartment of Medicine/Neurology, University of British Columbia, Vancouver, Canada.
Michael WinterdahlDepartment of Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark.
Aarhus University · DKMcGill University · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT PROCEDURES: Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [

resultsThe binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former.

conclusionsInteractions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.

Indexed as

Magnetic Resonance ImagingAnestheticsAnimalsBiomarkersBrainFemaleIsofluranePropofolReceptor, Serotonin, 5-HT2ARegional Blood FlowSwineSwine, MiniatureAnestheticsBiomarkersIsofluranePropofolReceptor, Serotonin, 5-HT2A[11C]MDL100,907AnimalGöttingen minipigIsofluranePETPropofolSerotoninSwine

Identifiers

PMID31993926
OpenAlexW3004025238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.