Evidence map›Paper›PMID 31993892›Full record

ArticleJournal of clinical monitoring and computing2021

An effective pressure-flow characterization of respiratory asynchronies in mechanical ventilation.

Alberto Casagrande, Francesco Quintavalle, Rafael Fernandez, Lluis Blanch, Massimo Ferluga, Enrico Lena, Francesco Fabris, Umberto Lucangelo

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of clinical monitoring and computing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. What is new in respiratory monitoring?Journal of clinical monitoring and computing · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto CasagrandeDepartments of Mathematics and Geosciences, University of Trieste, Via Valerio, 12/1, 34127, Trieste, Italy. acasagrande@units.it.ORCID http://orcid.org/0000-0002-8681-1482
Francesco QuintavalleDAI Emergenza Urgenza ed Accettazione, Azienda Sanitaria Univeritaria integrata di Trieste, Trieste, Italy.
Rafael FernandezCIBER Enfermedades Respiratorias, ICU, Hospital Sant Joan de Déu, Fundació Althaia, Manresa, Spain.
Lluis BlanchCritical Care Center, ParcTaulì Hospital Universitari, Institut d'Investigaciò i Innovaciò Parc Taulì I3PT, Universitat Autònoma de Barcelona, Barcelona, Spain.
Massimo FerlugaDAI Emergenza Urgenza ed Accettazione, Azienda Sanitaria Univeritaria integrata di Trieste, Trieste, Italy.
Enrico LenaDAI Emergenza Urgenza ed Accettazione, Azienda Sanitaria Univeritaria integrata di Trieste, Trieste, Italy.
Francesco FabrisDepartments of Mathematics and Geosciences, University of Trieste, Via Valerio, 12/1, 34127, Trieste, Italy.
Umberto LucangeloDAI Emergenza Urgenza ed Accettazione, Azienda Sanitaria Univeritaria integrata di Trieste, Trieste, Italy.

Funding

Gruppo Nazionale per l'Analisi Matematica, la Probabilitá e le loro Applicazioni Logic Programming for early detection of pancreatic cancerMinisterio de Industria, Turismo y Comercio (ES) and Ministerio de Ciencia, Innovación y Universidades (ES) Plan Avanza TSI-020302-2008-38
6 · The paper itself

Abstract

Ineffective effort during expiration (IEE) occurs when there is a mismatch between the demand of a mechanically ventilated patient and the support delivered by a Mechanical ventilator during the expiration. This work presents a pressure-flow characterization for respiratory asynchronies and validates a machine-learning method, based on the presented characterization, to identify IEEs. 1500 breaths produced by 8 mechanically-ventilated patients were considered: 500 of them were included into the training set and the remaining 1000 into the test set. Each of them was evaluated by 3 experts and classified as either normal, artefact, or containing inspiratory, expiratory, or cycling-off asynchronies. A software implementing the proposed method was trained by using the experts' evaluations of the training set and used to identify IEEs in the test set. The outcomes were compared with a consensus of three expert evaluations. The software classified IEEs with sensitivity 0.904, specificity 0.995, accuracy 0.983, positive and negative predictive value 0.963 and 0.986, respectively. The Cohen's kappa is 0.983 (with 95% confidence interval (CI): [0.884, 0.962]). The pressure-flow characterization of respiratory cycles and the monitoring technique proposed in this work automatically identified IEEs in real-time in close agreement with the experts.

Indexed as

Respiration, ArtificialVentilators, MechanicalExhalationHumansMachine LearningAutomatic monitoringMachine learningMechanical ventilatorRespiratory asynchrony

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.