Evidence map›Paper›PMID 31993873›Full record

ArticleWiener medizinische Wochenschrift (1946)2021

Clonal dissemination of high-level gentamicin-resistant isolates of Enterococcus faecalis within a university hospital in southeastern Iran.

Fereshteh Saffari, Hosein Darehkordi, Roya Ahmadrajabi

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Article in Wiener medizinische Wochenschrift (1946), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.0field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fereshteh SaffariStudent Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Hosein DarehkordiDepartment of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, end of 22-Bahman Street, Kerman, Iran.
Roya AhmadrajabiDepartment of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, end of 22-Bahman Street, Kerman, Iran. r.ahmadi@kmu.ac.ir.ORCID http://orcid.org/0000-0001-5636-7037
Kerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCombination of a cell wall-active antibiotic with an aminoglycoside confers a synergistic effect in the treatment of some severe enterococcal infections. Unfortunately, with the emergence of enterococci with high-level resistance to aminoglycosides, particularly to gentamicin, the efficacy of the synergistic combinations has decreased. In this study, high-level gentamicin-resistant (HLGR) isolates of enterococci and the diversity of the genes encoding aminoglycoside-modifying enzymes (AMEs) as well as putative clonal dissemination of HLGR isolates were investigated in a university hospital in southeastern Iran.

methodsThe minimum inhibitory concentration of gentamicin was determined and HLGR isolates were investigated for AME genes. Genetic similarity between isolates was analyzed using repetitive extragenic palindromic (rep)-Polymerase Chain Reaction (PCR) assay.

resultsOf 150 Enterococcus isolates, 62 isolates including Enterococcus faecalis (n = 46) and E. faecium (n = 16) were identified as HLGR. The most prevalent AME genes in both species were as follows: aph(3

conclusionsNo link between AME determinants and clusters was found. Clonal spread of HLGR isolates of E. faecalis was found within our hospital. More rigorous recommendations are required to avoid dissemination of such resistant microorganisms in the hospital setting.

Indexed as

Enterococcus faecalisEnterococcus faeciumAnti-Bacterial AgentsDrug Resistance, BacterialGentamicinsHumansIranAnti-Bacterial AgentsGentamicinsAminoglycoside modifying enzymeEnterococcus faecalisHigh-level gentamicin-resistantMinimum inhibitory concentrationRepetitive extragenic palindromic (rep)-PCR

Identifiers

PMID31993873
OpenAlexW3004121973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.