Evidence map›Paper›PMID 31993851›Full record

ArticleApoptosis : an international journal on programmed cell death2020

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization.

Lindsey M Ludwig, Lauren E Roach, Samuel G Katz, James L LaBelle

Open access · greenAbstract read
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lindsey M LudwigDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, 900 East 57th Street, KCBD 5122, Chicago, IL, 60637, USA.
Lauren E RoachDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, 900 East 57th Street, KCBD 5122, Chicago, IL, 60637, USA.
Samuel G KatzDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
James L LaBelleDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, 900 East 57th Street, KCBD 5122, Chicago, IL, 60637, USA. jlabelle@peds.bsd.uchicago.edu.ORCID 0000-0001-6776-4695
University of Chicago · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Pathologic BIM Suppression & Pharmacologic BH3 Replacement in B-Cell LymphomaK08CA151450 · NCI · UNIVERSITY OF CHICAGO · PI LABELLE, JAMES LAURENCE · 2011 to 2015
$842k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K08 CA151450NCI NIH HHS T32 CA009594
6 · The paper itself

Abstract

BIM is the master BH3-only BCL-2 family regulator of lymphocyte survival. To understand how long-term loss of BIM affects apoptotic resistance in T cells we studied animals with T cell-specific deletion of Bim. Unlike CD19

Indexed as

Cell DeathAnimalsApoptosisBcl-2-Like Protein 11HomeostasisLymphocyte CountLymphocytosisMiceMice, KnockoutMitochondriaProto-Oncogene Proteins c-bcl-2ThymocytesT-LymphocytesT-Lymphocyte SubsetsUp-RegulationBcl2l11 protein, mouseBcl-2-Like Protein 11Proto-Oncogene Proteins c-bcl-2ApoptosisBCL-2BIMT cells

Identifiers

PMID31993851
PMCPMC8265391
OpenAlexW3003697655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.