Evidence map›Paper›PMID 31993755›Full record

ArticleArchives of osteoporosis2020

Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model.

Alla Zakroyeva, Olga Lesnyak, Victor Cazac, Liliana Groppa, Eugen Russu, Lia Chislari, Larisa Rotaru, Helena Johansson, Nicholas C Harvey, Eugene McCloskey and 2 more

Abstract read
In one paragraph

Article in Archives of osteoporosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: implications for Fracture Risk Assessment Tool (FRAX)-derived estimates.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Pooled it
  2. Article
  3. Article
  4. A surrogate FRAX model for Mongolia.Archives of osteoporosis · 2025
    Article
  5. A surrogate FRAX model for Nepal.Archives of osteoporosis · 2024
    Article
  6. Article
  7. Article
  8. A country-specific FRAX model for Botswana.Archives of osteoporosis · 2021
    Article
  9. Article
  10. Study on Omentin-1 and miR-502-3p in osteoporotic fracture.Journal of musculoskeletal & neuronal interactions · 2021
    Article
  11. Article
  12. A surrogate FRAX model for Pakistan.Archives of osteoporosis · 2021
    Article
  13. Epidemiology of hip fracture in Botswana.Archives of osteoporosis · 2021
    Article
  14. Article
  15. A surrogate FRAX model for the Kyrgyz Republic.Archives of osteoporosis · 2020
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alla ZakroyevaUral State Medical University, 3 Repina street, Yekaterinburg, Russia, 620028.
Olga LesnyakNorth West State Medical University named after I.I. Mechnikov, 41, Kirochnaya street, St. Petersburg, Russia, 191015.
Victor CazacState University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant blvd., 2004, Chisinau, Republic of Moldova.
Liliana GroppaState University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant blvd., 2004, Chisinau, Republic of Moldova.
Eugen RussuState University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant blvd., 2004, Chisinau, Republic of Moldova.
Lia ChislariState University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant blvd., 2004, Chisinau, Republic of Moldova.
Larisa RotaruState University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant blvd., 2004, Chisinau, Republic of Moldova.
Helena JohanssonMary McKillop Health Institute, Catholic University of Australia, Melbourne, Australia.
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Eugene McCloskeyCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
Mattis LorentzonGeriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
John A KanisMary McKillop Health Institute, Catholic University of Australia, Melbourne, Australia. w.j.pontefract@sheffield.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment.

objectiveThis paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool.

methodsWe carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country's population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models.

resultsThe incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania).

conclusionThe FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.

Indexed as

Decision Support TechniquesAgedFemaleForearm InjuriesHip FracturesHumansHumeral FracturesIncidenceMaleMiddle AgedMoldovaOsteoporotic FracturesProbabilityRegistriesRetrospective StudiesRisk AssessmentEpidemiologyFracture probabilityFRAXHip fracture

Identifiers

PMID31993755
PMCPMC6987067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.