Evidence map›Paper›PMID 31993714›Full record

ArticleDiabetologia2020

Impact of diabetes on colorectal cancer stage and mortality risk: a population-based cohort study.

Judy K Qiang, Rinku Sutradhar, Vasily Giannakeas, Dominika Bhatia, Simron Singh, Lorraine L Lipscombe

Abstract read
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In one paragraph

Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Diabetes and Cancer: A Twisted Bond.Oncology reviews · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Judy K QiangDepartment of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON, Canada.
Rinku SutradharInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Vasily GiannakeasICES, Toronto, ON, Canada.
Dominika BhatiaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Simron SinghICES, Toronto, ON, Canada.
Lorraine L LipscombeDepartment of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON, Canada. Lorraine.Lipscombe@wchospital.ca.

Funding

OICR N/A
6 · The paper itself

Abstract

aims/hypothesisDiabetes is associated with an increased incidence of colorectal cancer (CRC). There exists conflicting evidence regarding the impact of diabetes on CRC-specific mortality (herein also referred to as cancer-specific mortality). The objectives of this study were to determine whether diabetes is associated with a more advanced CRC stage at diagnosis and with higher all-cause and cancer-specific mortality.

methodsThis retrospective cohort study used linked, population-based health databases from Ontario, Canada. Among individuals diagnosed with CRC from 2007 to 2015, we compared the likelihood of presenting with later- (III or IV) vs early- (I or II) stage CRC between patients with and without diabetes adjusting for relevant covariates. We then determined the association between diabetes and all-cause and CRC-specific mortality, after adjusting for CRC stage at diagnosis and other covariates.

resultsOf the 44,178 individuals with CRC, 11,822 (26.7%) had diabetes. After adjustment for CRC screening and other covariates, individuals with diabetes were not more likely to present with later-stage CRC (adjusted OR 0.97, 95% CI 0.93, 1.01). Over a median follow-up of 2.63 (interquartile range [IQR] 0.97-5.10) years, diabetes was associated with higher all-cause mortality (adjusted HR 1.08, 95% CI 1.04, 1.12) but similar cancer-specific survival (adjusted HR 1.0, 95% CI 0.95, 1.06). CONCLUSIONS/

interpretationIndividuals with diabetes who develop CRC are not more likely to present with a later stage of CRC and have similar cancer-specific mortality compared with those without diabetes. Diabetes was associated with higher all-cause mortality in CRC patients, indicating that greater attention to non-cancer care is needed for CRC survivors with diabetes.

Indexed as

Cohort StudiesColorectal NeoplasmsDiabetes MellitusHumansIncidenceLogistic ModelsOntarioRetrospective StudiesColorectal cancer mortalityColorectal cancer stageDiabetes mellitus

Identifiers

PMID31993714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.