ArticleSocial cognitive and affective neuroscience2019
Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Interpersonal emotion regulation in dementia: Diagnostic differences and associations with caregiver mental health.Emotion (Washington, D.C.) · 2026Article
- Lower income level is associated with less favorable health trajectories in caregivers of people with neurodegenerative disease after caregiving ends.Aging & mental health · 2025Article
- Diminished preparatory physiological responses in people with dementia: associations with caregiver health and relationship quality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Interpersonal Physiological Linkage Between People With Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease and Their Informal Caregivers.Psychophysiology · 2025Article
- The neutral past: emotional (dys)regulation of autobiographical memory in behavioural variant frontotemporal dementia.Cognitive neuropsychiatry · 2023Article
- Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson's disease.PloS one · 2023Article
- Incongruences Between Facial Expression and Self-Reported Emotional Reactivity in Frontotemporal Dementia and Related Disorders.The Journal of neuropsychiatry and clinical neurosciences · 2023Article
- Behavioural subphenotypes and their anatomic correlates in neurodegenerative disease.Brain communications · 2023Article
- Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateralized atrophy in the temporal and frontal lobes.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Spatial statistical analysis of the relationship between self-reported mental health during the COVID-19 lockdown and closeness to green infrastructure.Urban forestry & urban greening · 2022Article
- Metacognition of emotion recognition across neurodegenerative diseases.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Frontotemporal dementia (FTD), a neurodegenerative disease broadly characterized by socioemotional impairments, includes three clinical subtypes: behavioral variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non-fluent variant primary progressive aphasia (nfvPPA). Emerging evidence has shown emotional reactivity impairments in bvFTD and svPPA, whereas emotional reactivity in nfvPPA is far less studied. In 105 patients with FTD (49 bvFTD, 31 svPPA and 25 nfvPPA) and 27 healthy controls, we examined three aspects of emotional reactivity (physiology, facial behavior and subjective experience) in response to a sad film. In a subset of the sample, we also examined the neural correlates of diminished aspects of reactivity using voxel-based morphometry. Results indicated that all three subtypes of FTD showed diminished physiological responding in respiration rate and diastolic blood pressure; patients with bvFTD and svPPA also showed diminished subjective experience, and no subtypes showed diminished facial behavior. Moreover, there were differences among the clinical subtypes in brain regions where smaller volumes were associated with diminished sadness reactivity. These results show that emotion impairments extend to sadness reactivity in FTD and underscore the importance of considering different aspects of sadness reactivity in multiple clinical subtypes for characterizing emotional deficits and associated neurodegeneration in FTD.
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