ArticleMayo Clinic proceedings. Innovations, quality & outcomes2019
Post-Transfusion Hemophagocytosis Without Hemophagocytic Lymphohistiocytosis.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Secondary hemophagocytic lymphohistiocytosis following blood transfusion in the absence of an identifiable trigger.SAGE open medical case reports · 2026Article
- Assessment of Hemophagocytic Lympho-Histiocytosis (HLH) in the Setting of Adult Acute Liver Failure.Journal of viral hepatitis · 2025Article
- Thrombocytopenia, anasarca, and severe inflammation.American journal of hematology · 2022Article
- COVID-19, haemophagocytic lymphohistiocytosis, and infection-induced cytokine storm syndromes.The Lancet. Infectious diseases · 2022Article
- Hemophagocytic Lymphohistiocytosis Secondary to Immune Checkpoint Inhibitor Therapy.World journal of oncology · 2022Review
- A Case of Secondary Hemophagocytic Lymphohistiocytosis Presenting with Severe Dyserythropoeisis in a Patient with Autoimmune Hemolysis.Case reports in hematology · 2022Article
- Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma.Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
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5 authors.
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Abstract
Hemophagocytosis refers to ingestion of hematopoietic elements or mature blood cells by another cell, typically by cells conventionally associated with phagocytic capacity. Although the finding of hemophagocytosis as a prominent feature in a patient's bone marrow might prompt consideration of a hemophagocytic syndrome (HPS) such as hemophagocytic lymphohistiocytosis (HLH) in a clinician's or pathologist's differential diagnosis, this morphologic feature can be nonspecific in the absence of other clinical and laboratory features of pathologic immune activation, which is the sine qua non of HPS/HLH. We describe three patients whose clinical presentations included transfusion-dependent anemia and whose bone marrow aspirates showed unexpectedly brisk hemophagocytosis of mature red blood cells. Despite striking morphologic hemophagocytosis, no patient met criteria for diagnosis of an HPS. Transfusion-associated hemophagocytosis and hyperferritinemia must be carefully distinguished from HLH through clinical and laboratory assessment. Biomarkers of pathologic immune activation are important diagnostic aids.
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