ArticleNature metabolism2020
Somatostatin secretion by Na
Open access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.Annals of the New York Academy of Sciences · 2026Review
- Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells.Communications biology · 2026Article
- Heterogeneous endocrine cell composition defines human islet functional phenotypes.Nature communications · 2026Article
- Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.Nature metabolism · 2026Article
- Review
- Heterogeneous endocrine cell composition defines human islet functional phenotypes.bioRxiv : the preprint server for biology · 2025Article
- Ryanodine Receptors in Islet Cell Function: Calcium Signaling, Hormone Secretion, and Diabetes.Cells · 2025Review
- Dehydration-induced AVP stimulates glucagon release and ketogenesis.American journal of physiology. Endocrinology and metabolism · 2025Article
- Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders.International journal of molecular sciences · 2025Review
- Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes.Acta physiologica (Oxford, England) · 2025Article
- Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.Nature metabolism · 2024Article
- Directed differentiation of pancreatic δ cells from human pluripotent stem cells.Nature communications · 2024Article
- The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes.International journal of molecular sciences · 2024Review
- GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.Diabetologia · 2024Article
- Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β cells.JCI insight · 2024Article
- Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.International journal of molecular sciences · 2023Article
- Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes.Frontiers in pharmacology · 2023Review
- GNature communications · 2022Article
- Liraglutide increases islet CaDiabetes, obesity & metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Elisa Vergari *Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Geoffrey Denwood *Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Albert Salehi *Department of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.ORCID http://orcid.org/0000-0001-6120-3539
Quan Zhang *Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-3626-4855
Julie AdamNuffield Department of Clinical Medicine, University of Oxford, NDM Research Building, Oxford, UK.
Ahmed AlrifaiyDepartment of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.
Ingrid Wernstedt AsterholmDepartment of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.ORCID http://orcid.org/0000-0002-0755-5784
Anna BenrickDepartment of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.
Margarita V ChibalinaOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Lena EliassonDepartment of Clinical Sciences Malmö, Clinical Research Centre, Malmö, Sweden.ORCID http://orcid.org/0000-0002-6467-5029
Claudia GuidaOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Thomas G HillOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Alexander HamiltonOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Reshma RamracheyaOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Frank ReimannMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9399-6377
Nils J G RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Ioannis SpilliotisOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Andrei I TarasovOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-8883-176X
Jonathan N WalkerOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK.
Patrik RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK. patrik.rorsman@gu.se.ORCID http://orcid.org/0000-0001-7578-0767
Linford J B BriantOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford, UK. linford.briant@ocdem.ox.ac.uk.ORCID http://orcid.org/0000-0003-3619-3177
Churchill Hospital · GBLund University · SEUniversity of Gothenburg · SEUniversity of Oxford · GBUniversity of Cambridge · GB
Funding
Diabetes UK 12/0004622Medical Research Council G0801995Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Medical Research Council MR/T002107/1Wellcome Trust 084210Wellcome Trust 095531Wellcome Trust 095531/Z/11/ZWellcome Trust 106262Wellcome Trust 106263/Z/14/ZWellcome Trust 201325Wellcome Trust 201325/Z/16/Z
Abstract
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells
Indexed as
AnimalsCalciumDiabetes Mellitus, Type 2GlucagonGlucoseHumansHypoglycemiaInsulinMiceSodiumSomatostatinSomatostatin-Secreting CellsCalciumGlucagonGlucoseInsulinSodiumSomatostatin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.