ArticleOpen forum infectious diseases2020
Eosinopenia and Binary Toxin Increase Mortality in Hospitalized Patients With
Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Silent existence of eosinopenia in sepsis: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Multi-strain Clostridioides difficile infection: Increased detection and clinical implications.The Journal of infection · 2026Article
- Clostridioides difficile : A suspected pro-carcinogenic bacterium for gastrointestinal tumors.Chinese medical journal · 2026Review
- Exploring the etiology of colitis: insights from gut microbiota research.Gut microbes · 2025Review
- The interplay between host immunity andmBio · 2025Review
- Controversies in the Prevention and Treatment ofMicroorganisms · 2023Review
- An Update onToxins · 2022Review
- Neutrophil Ratio of White Blood Cells as a Prognostic Predictor ofJournal of inflammation research · 2022Article
- Article
- Assessment of Kidney Injury as a Severity Criteria forOpen forum infectious diseases · 2020Article
- In vitro activity of eravacycline against common ribotypes of Clostridioides difficile.The Journal of antimicrobial chemotherapy · 2020Article
- Article
- Emergency department eosinophil counts and mortality in Clostridium difficile: a multihospital retrospective cohort study.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPatients with
methodsThis multicenter, retrospective cohort study included adult patients with CDI of known ribotypes stratified by eosinopenia, defined as an absence of eosinophils in the peripheral blood (Houston cohort). The primary outcome was inpatient mortality. Results were supported by a separate national cohort of veterans with CDI (Veterans' cohort).
resultsIn the Houston cohort, a total of 688 patients from 13 institutions in 6 cities were included. Of these, 132 (19%) had an eosinophil count of 0.0 cells/µL (0.0 cells*10
conclusionsIn conclusion, the combination of eosinopenia and CDI due to a binary toxin strain was correlated with increased mortality in hospitalized patients from 2 independent cohorts. Prospective studies should further study this important subset of patients at the time of CDI diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.