Evidence map›Paper›PMID 31993369›Full record

ArticleFrontiers in oncology2019

A Specific Blood Signature Reveals Higher Levels of S100A12: A Potential Bladder Cancer Diagnostic Biomarker Along With Urinary Engrailed-2 Protein Detection.

Ayssar A Elamin, Saskia Klunkelfuß, Susanne Kämpfer, Wulf Oehlmann, Matthias Stehr, Christopher Smith, Guy R Simpson, Richard Morgan, Hardev Pandha, Mahavir Singh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Liquid biopsy in bladder cancer: towards precision oncology.Journal of translational medicine · 2026
    Review
  2. Article
  3. Advances in Liquid Biopsy for Diagnosis of Bladder Cancer.International neurourology journal · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ayssar A ElaminLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Saskia KlunkelfußLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Susanne KämpferLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Wulf OehlmannLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Matthias StehrLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Christopher SmithDepartment of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Guy R SimpsonDepartment of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Richard MorganInstitute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford, United Kingdom.
Hardev PandhaDepartment of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Mahavir SinghLIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.
Lionex (Germany) · DEUniversity of Surrey · GBUniversity of Bradford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial carcinoma of the urinary bladder (UCB) or bladder cancer remains a major health problem with high morbidity and mortality rates, especially in the western world. UCB is also associated with the highest cost per patient. In recent years numerous markers have been evaluated for suitability in UCB detection and surveillance. However, to date none of these markers can replace or even reduce the use of routine tools (cytology and cystoscopy). Our current study described UCB's extensive expression profile and highlighted the variations with normal bladder tissue. Our data revealed that

Indexed as

bladdercancerEN2lateral flowmicroarrayplasmaS100A12urine

Identifiers

PMID31993369
PMCPMC6962349
OpenAlexW3000744571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.