ArticleToxicology reports2020
Acute and subchronic oral toxicity assessments of
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- Evaluation of the Cytotoxicity, Genotoxicity and Acute Oral Toxicity ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Acute and Subacute Oral Toxicity Assessment of Kinkeliba (Plants (Basel, Switzerland) · 2025Article
- Evaluation of acute and sub-acute toxicity ofResearch in pharmaceutical sciences · 2025Article
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- Exploring the Nutritional and Antimicrobial Properties of Wild Fruit,Scientifica · 2025Article
- Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study.BMC complementary medicine and therapies · 2024Article
- Evaluation of Acute and Sub-Chronic Toxicity ofAdvanced biomedical research · 2024Article
- Evaluation of the Hepatoprotective Properties of Traditional Formulations Based onAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Pharmacognostic characterization, wound healing and toxicity assessment of the stem bark ofHeliyon · 2023Article
- Anti-cholinesterase, anti-inflammatory and antioxidant properties ofIBRO neuroscience reports · 2023Article
- Article
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- Sub-acute toxicity study on hydromethanolic leaves extract ofToxicological research · 2022Article
- Review
- Nephroprotective Effects ofMolecules (Basel, Switzerland) · 2022Article
- A New Calcium(II)-Based Substitute for Enrofloxacin with Improved Medicinal Potential.Pharmaceutics · 2022Article
- Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria.European journal of integrative medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAIM OF THE STUDY: The study carried out to evaluates the potential toxicity of the hydroalcoholic extract from leaves of the CM, through the method of acute and sub-chronic oral administration in rats. MATERIALS AND
methodsDuring the acute toxicity study, male and female rats were orally administrated with CM extract at single doses of 5000 mg/kg (n = 5/group/sex). Abnormal behaviour, toxic symptoms, weight, and death were observed for 14 consecutive days to assess the acute toxicity. For sub-chronic toxicity study, the extract was administered orally at doses of 500 and 1000 mg/kg (n = 5/group/sex) daily to Wistar rats for 28 days. The general behaviour and body weight of the rats was observed daily. A biochemical, haematological, macroscopical and histopathological examinations of several organs were conducted at the end of the treatment period. The CM extract was subjected to Fourier transform infrared spectrophotometric examination in order to detect the presence or absence of cyanide toxic compounds.
resultsThe absence of absorbance peaks between the 2220-2260 cm
conclusionThe present study revealed that oral administration of CM extract for 28 days, at dosage up to 1000 mg/kg did not induce toxicological damage in rats. From acute toxicity study, the median lethal dose (LD
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