Evidence map›Paper›PMID 31993314›Full record

ArticleActa pharmaceutica Sinica. B2020

Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice.

Pei Wang, Xueyan Shao, Yifan Bao, Junjie Zhu, Liming Chen, Lirong Zhang, Xiaochao Ma, Xiao-Bo Zhong

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Pei WangDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xueyan ShaoDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Yifan BaoDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Junjie ZhuDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Liming ChenDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Lirong ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xiaochao MaDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Xiao-Bo ZhongDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
University of Connecticut · USUniversity of Pittsburgh · USZhengzhou University · CN

Funding

Short- or long-term impacts of drug exposure at early life on drug metabolism, therapeutic efficacy, and drug-induced toxicityR01GM118367 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI ZHONG, XIAO-BO · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM118367
6 · The paper itself

Abstract

The prevalence of obesity-associated conditions raises new challenges in clinical medication. Although altered expression of drug-metabolizing enzymes (DMEs) has been shown in obesity, the impacts of obese levels (overweight, obesity, and severe obesity) on the expression of DMEs have not been elucidated. Especially, limited information is available on whether parental obese levels affect ontogenic expression of DMEs in children. Here, a high-fat diet (HFD) and three feeding durations were used to mimic different obese levels in C57BL/6 mice. The hepatic expression of five nuclear receptors (NRs) and nine DMEs was examined. In general, a trend of induced expression of NRs and DMEs (except for

Indexed as

18-HA, adult mice fed with 18 weeks HFD18-LA, adult mice fed with 18 weeks LFD4-HA, adult mice fed with 4 weeks HFD4-LA, adult mice fed with 4 weeks LFD7-ER, 7-ethoxyresorufin8-HA, adult mice fed with 8 weeks HFD8-LA, adult mice fed with 8 weeks LFDAhR, aryl hydrocarbon receptorBMI, body mass indexCAR, constitutive androstane receptorCHZ, chlorzoxazoneCYP2E1, cytochrome P450 2E1Diet-induced obesityDIO, diet-induced obesityDMEs, drug-metabolizing enzymesDrug-metabolizing enzymesEFV, efavirenzGapdh, glyceraldehyde-3-phosphate dehydrogenaseHFD, high-fat dietHigh-fat dietHNF4α, hepatocyte nuclear factor 4 alphaLFD, low-fat dietMDZ, midazolamMPA, mobile phase AMPB, mobile phase BNADPH, nicotinamide adenine dinucleotide phosphateNAFLD, non-alcoholic fatty liver diseaseNRs, nuclear receptorsNuclear receptorsO-18-HA, offspring from parental mice fed with 18 weeks HFDO-18-LA, offspring from parental mice fed with 18 weeks LFDO-4-HA, offspring from parental mice fed with 4 weeks HFDO-4-LA, offspring from parental mice fed with 4 weeks LFDO-8-HA, offspring from parental mice fed with 8 weeks HFDO-8-LA, offspring from parental mice fed with 8 weeks LFDOntogenic expressionOverweightPBS, phosphate-buffered salinePPARα, peroxisome proliferator-activated receptor alphaPXR, pregnane X receptorRSF, resorufinRT-qPCR, real-time quantitative PCRSD, standard deviationSULT1A1, sulfotransferase 1A1UGT1A1, uridine diphosphate glucuronosyltransferase 1A1

Identifiers

PMID31993314
PMCPMC6976990
OpenAlexW2991448438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.