ArticleFood science & nutrition2020
Rice-derived peptide AAGALPS inhibits TNF-α-induced inflammation and oxidative stress in vascular endothelial cells.
Article in Food science & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- A halophilic metalloprotease fromFrontiers in microbiology · 2025Article
- Antioxidant Function and Application of Plant-Derived Peptides.Antioxidants (Basel, Switzerland) · 2024Review
- Advances in Research on the Activity Evaluation, Mechanism and Structure-Activity Relationships of Natural Antioxidant Peptides.Antioxidants (Basel, Switzerland) · 2024Review
- Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Review
- Effects of sesame (Food science & nutrition · 2023Review
- Monotropein alleviates H2O2‑induced inflammation, oxidative stress and apoptosis via NF‑κB/AP‑1 signaling.Molecular medicine reports · 2020Article
- Rice-derived peptide AAGALPS inhibits TNF-α-induced inflammation and oxidative stress in vascular endothelial cells.Food science & nutrition · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury of vascular endothelial cell is one of the main factors triggering atherosclerosis. Peptide AAGALPS was derived from digestion and absorption product of rice α-globulin, which was proved to prevent atherosclerosis in previous study. This study aims to investigate the potential effects of AAGALPS on improving tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells' (HUVECs) injury. As a result, the viability of HUVECs stimulated by tumor necrosis factor-α was significantly increased by AAGALPS in a dose-dependent manner until 25 μg/ml. The peptide obviously reduced the levels of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, nitric oxide, inducible nitric oxide synthase, reactive oxygen species, and malondialdehyde and increased the concentrations of glutathione peroxidase. Furthermore, AAGALPS inhibited the nuclear factor κB (NF-κB) activation and nuclear translocation through regulating inhibitor of nuclear factor κB kinase α and inhibitor of NF-κB. These results indicated that AAGALPS protected vascular endothelial cells through mediating inflammation and oxidative stress.
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