ArticleMolecular autism2020
Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults.
Article in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Autistic Trait Level and Reaction Time in Older Adults: The Influence of Sex and Task upon Study Outcome.Autism in adulthood · 2026Article
- Article
- Quantifying Similarity of Dynamic Brain Networks: Two Novel Indices for Structural Change and Temporal Evolution.Bioengineering (Basel, Switzerland) · 2025Article
- Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.Sao Paulo medical journal = Revista paulista de medicina · 2025Review
- Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Exploring crystallized and fluid intelligence in down syndrome using graph theory.Scientific reports · 2024Article
- Probing the overarching continuum theory: data-driven phenotypic clustering of children with ASD or ADHD.European child & adolescent psychiatry · 2023Article
- Altered brain network organization in adults with Asperger's syndrome: decreased connectome transitivity and assortativity with increased global efficiency.Frontiers in psychiatry · 2023Article
- Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.Autism research : official journal of the International Society for Autism Research · 2022Article
- Electrophysiological signatures of brain aging in autism spectrum disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water.Frontiers in aging neuroscience · 2022Article
- Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development.Frontiers in psychiatry · 2022Article
- Ageing and heterogeneity regarding autism spectrum conditions: a protocol paper of an accelerated longitudinal study.BMJ open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The majority of research effort into autism has been dedicated to understanding mechanisms during early development. As a consequence, research on the broader life course of an autism spectrum condition (ASC) has largely been neglected and almost nothing is known about ASC beyond middle age. Differences in brain connectivity that arise during early development may be maintained across the lifespan and may play protective or detrimental roles in older age. Method: This study explored age-related differences in functional connectivity across middle and older age in clinically diagnosed autistic adults ( Results: The results indicated parallel age-related associations in ASC and typical aging for the local efficiency and connection strength of the default mode network and for the segregation of the frontoparietal control network. In contrast, group differences in visual network connectivity are compatible with a safeguarding interpretation of less age-related decline in brain function in ASC. This divergence was mirrored in different associations between visual network connectivity and reaction time variability in the ASC and comparison group. Limitations: The study is cross-sectional and may be affected by cohort effects. As all participants received their autism diagnosis in adulthood, this might hinder generalizability. Conclusion: These results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.