Evidence map›Paper›PMID 31993078›Full record

ArticleEvolutionary applications2020

Combining genetic crosses and pool targeted DNA-seq for untangling genomic variations associated with resistance to multiple insecticides in the mosquito

Julien Cattel, Frédéric Faucon, Bastien Le Péron, Stéphanie Sherpa, Marie Monchal, Lucie Grillet, Thierry Gaude, Frederic Laporte, Isabelle Dusfour, Stéphane Reynaud and 1 more

Open access · goldAbstract read
In one paragraph

Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Julien CattelLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Frédéric FauconLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Bastien Le PéronLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Stéphanie SherpaLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Marie MonchalLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Lucie GrilletLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Thierry GaudeLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Frederic LaporteLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Isabelle DusfourInstitut Pasteur de la Guyane Cayenne France.
Stéphane ReynaudLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.
Jean-Philippe DavidLaboratoire d'Ecologie Alpine (LECA) UMR 5553 CNRS - Université Grenoble-Alpes Grenoble France.ORCID https://orcid.org/0000-0002-3950-5909
Centre National de la Recherche Scientifique · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to combating vector-borne diseases, studying the adaptation of mosquitoes to insecticides provides a remarkable example of evolution-in-action driving the selection of complex phenotypes. Actually, most resistant mosquito populations show multi-resistance phenotypes as a consequence of the variety of insecticides employed and of the complexity of selected resistance mechanisms. Such complexity makes the identification of alleles conferring resistance to specific insecticides challenging and prevents the development of molecular assays to track them in the field. Here we showed that combining simple genetic crosses with pool targeted DNA-seq can enhance the specificity of resistance allele's detection while maintaining experimental work and sequencing effort at reasonable levels. A multi-resistant population of the mosquito

Indexed as

Aedes aegypticomplex phenotypecopy number variationscytochromes P450sdetoxification enzymesinsecticide resistancemosquitopolymorphism

Identifiers

PMID31993078
PMCPMC6976963
OpenAlexW2972603645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.